Document Detail

Effectiveness of a heat and moisture exchanger in preventing hyperpnoea induced bronchoconstriction in subjects with asthma.
MedLine Citation:
PMID:  3424269     Owner:  NLM     Status:  MEDLINE    
The effect of a heat and moisture exchanger, a device with hygroscopic material for conditioning inspired air, on hyperpnoea induced bronchoconstriction was studied in nine non-smoking volunteers with asthma, aged 19-32 years. Each had previously shown an increase of at least 100% in specific airways resistance (sRaw) to isocapnic hyperpnoea with dry air. On two separate days the subject performed isocapnic hyperpnoea with dry air at 60-70 l min-1 for five minutes. Before, immediately after, and five minutes after completion of a test sRaw measurements were made. Heat and moisture exchangers were placed in the breathing circuit on one of the two days. All subjects had an increase in sRaw of 100% or more without the heat and moisture exchangers (average increase 300%) but were protected from bronchoconstriction with the devices in place (average increase 7%) (p less than 0.005). The exchanger's resistance to airflow was less than 1 cm H2O for flow rates of 100 l min-1. A heat and moisture exchanger designed as a facemask or mouthpiece may allow a person with asthma to exercise without the need for prophylactic drugs.
T R Gravelyn; M Capper; W L Eschenbacher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thorax     Volume:  42     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-02-25     Completed Date:  1988-02-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  877-80     Citation Subset:  IM    
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0026.
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MeSH Terms
Airway Resistance
Asthma / physiopathology,  prevention & control*
Bronchial Provocation Tests
Hot Temperature
Respiratory Therapy / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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