Document Detail


Effectiveness of galactose-based intravenous contrast medium on color Doppler sonography of deeply located hepatocellular carcinoma.
MedLine Citation:
PMID:  7571125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study is to examine the effectiveness of intravenously injectable sonographic contrast medium for color Doppler sonographic diagnosis of deeply located hepatocellular carcinoma. Subjects were 7 hepatocellular carcinomas, an adenomatous hyperplasia and a hemangioma located more than 7 cm below the abdominal surface. Levovist, a galactose-based sonographic contrast medium was injected through median cubital vein as a phase-two clinical study, and the pre- and post-enhanced color Doppler sonographic findings of these lesions were compared. The incidence of the positive findings for hepatocellular carcinoma increased from 29% (2/7) to 86% (6/7) of hepatocellular carcinoma after contrast enhancement. Positive findings were 0% in other cases even after enhancement. Levovist brought a certain improvement in the visualization of the tumor vessel by color Doppler sonography without any noteworthy side effects. Contrast enhancement was useful for the diagnosis of liver lesions suspected to be hepatocellular carcinoma by ordinary sonography, but could not be confirmed by color Doppler sonography.
Authors:
S Tanaka; T Kitamra; F Yoshioka; S Kitamura; K Yamamoto; Y Ooura; T Imaoka
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  21     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-26     Completed Date:  1995-10-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  157-60     Citation Subset:  IM    
Affiliation:
Center for Adult Diseases, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Flow Velocity
Carcinoma, Hepatocellular / blood supply,  ultrasonography*
Chronic Disease
Contrast Media*
Female
Galactose / diagnostic use*
Hepatitis / ultrasonography
Humans
Injections, Intravenous
Liver Circulation
Liver Cirrhosis / ultrasonography
Liver Neoplasms / blood supply,  ultrasonography*
Male
Middle Aged
Polysaccharides / diagnostic use
Ultrasonography, Doppler, Color*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508; 26566-61-0/Galactose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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