Document Detail

Effectiveness of fosfomycin combined with other antimicrobial agents against multidrug-resistant Pseudomonas aeruginosa isolates using the efficacy time index assay.
MedLine Citation:
PMID:  11957118     Owner:  NLM     Status:  MEDLINE    
We investigated the effectiveness of fosfomycin combined with other antibiotics, such as piperacillin, cefepime, ceftazidime, imipenem, meropenem, aztreonam, gentamicin, or levofloxacin, against 30 Pseudomonas aeruginosa strains, including multidrug-resistant strains, isolated from clinical specimens, using the efficacy time index (ETI) assay. The assay refers to the result of pharmacokinetics obtained from adult men volunteers, and yields an ETI to evaluate the effect of a combination of antimicrobial agents. With the ETI, based on serum concentration 3 h after the administration of two antimicrobial agents, the effectiveness of antimicrobial combinations was evaluated as follows: poor, ETI < 0.5; fair, 0.5 < or = ETI < 1; good, 1 < or = ETI < 8; and excellent, ETI > or = 8. The combination of fosfomycin and cefepime (efficacy rate [excellent plus good], 76.7%) and fosfomycin/aztreonam (efficacy rate, 76.7%) appeared to be the most effective, followed by fosfomycin/meropenem (efficacy rate, 76.6%), fosfomycin/imipenem (efficacy rate, 73.3%), fosfomycin/ceftazidime (efficacy rate, 70%), fosfomycin/gentamicin (efficacy rate, 70%), fosfomycin/piperacillin (efficacy rate, 66.7%), and fosfomycin/levofloxacin (efficacy rate, 66.7%). Fosfomycin/cefepime, fosfomycin/aztreonam, and fosfomycin/meropenem may be clinically useful in selected patients, particularly for P. aeruginosa. The ETI assay provided information on the minimum inhibitory concentration (MIC) of many pairs of combined antimicrobial agents simultaneously. The ETI assay may be a useful technique with which to investigate the effect of combinations of antimicrobial agents against P. aeruginosa, including multidrug-resistant strains.
Mitsuhiro Okazaki; Kyoko Suzuki; Noriko Asano; Koji Araki; Naoko Shukuya; Teruo Egami; Yoshimi Higurashi; Koji Morita; Hidemasa Uchimura; Takashi Watanabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     Volume:  8     ISSN:  1341-321X     ISO Abbreviation:  J. Infect. Chemother.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-16     Completed Date:  2002-05-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9608375     Medline TA:  J Infect Chemother     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Department of Clinical Laboratory, Kyorin University Hospital, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.
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MeSH Terms
Drug Resistance, Bacterial
Drug Resistance, Multiple
Drug Therapy, Combination / pharmacology*
Fosfomycin / pharmacology*
Microbial Sensitivity Tests / methods*
Pseudomonas aeruginosa / drug effects*
Reg. No./Substance:

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