Document Detail

Effectiveness of early prednisone treatment in preventing the development of nephropathy in anaphylactoid purpura.
MedLine Citation:
PMID:  1343079     Owner:  NLM     Status:  MEDLINE    
A prospective study was performed to verify whether early administration of prednisone could be useful in preventing the development of nephropathy in anaphylactoid purpura. Only patients without signs of nephropathy upon initial presentation entered into the study. A total of 84 patients received delta-prednisone (1 mg/kg per day per os for 2 weeks), and 84 patients did not receive steroids. The patients were followed for 24-36 months. None of the 84 patients treated with steroids and 10 (11.9%) of the 84 control patients developed nephropathy 2-6 weeks after the acute episode. In 2 other patients of the untreated group, signs of renal involvement appeared 2 and 6 years after the acute episode respectively. The difference in the prevalence of nephropathy between the two groups is highly significant (P less than 0.001).
F Mollica; S Li Volti; R Garozzo; G Russo
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  151     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  140-4     Citation Subset:  IM    
Department of Paediatrics, University of Catania, Italy.
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MeSH Terms
Administration, Oral
Child, Preschool
Kidney Diseases / prevention & control*
Prednisone / administration & dosage,  therapeutic use*
Prospective Studies
Purpura, Schoenlein-Henoch / drug therapy*,  immunology
Time Factors
Reg. No./Substance:
Comment In:
Eur J Pediatr. 1993 Sep;152(9):782   [PMID:  8223818 ]
Eur J Pediatr. 1993 Sep;152(9):782-3   [PMID:  8223819 ]

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