| Effectiveness of early medical abortion using low-dose mifepristone and buccal misoprostol in women with no defined intrauterine gestational sac. | |
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MedLine Citation:
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PMID: 23158804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The study was conducted to assess the effectiveness of early medical abortion (EMA) in women with early pregnancy and no defined intrauterine gestational sac (IUGS) on ultrasound. STUDY DESIGN: Retrospective, multicenter, observational study of oral mifepristone 200 mg and buccal misoprostol 800 mcg administered 24-48 h later for EMA (gestations ≤63 days). Odds ratios (ORs) [95% confidence intervals (CIs)] of EMA failure and continuing pregnancy for women with no defined IUGS vs. those with confirmed IUGS were calculated. RESULTS: Women with no defined IUGS were more likely to experience EMA failure [9.0% (6/67) vs. 3.5% (465/13,345); OR (95% CI)=2.72 (1.17-6.33), p=.041] and continuing pregnancy [7.5% (5/67) vs. 0.6% (83/13,345); OR (95% CI)=12.72 (4.98-32.46), p<.001]. CONCLUSION: EMA failure is more likely in women with early pregnancy and no defined IUGS than those with gestations ≤63 days and confirmed IUGS. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry identifier: ACTRN12611001051932. |
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Authors:
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Philip Goldstone; Jill Michelson; Eve Williamson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-15 |
Journal Detail:
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Title: Contraception Volume: - ISSN: 1879-0518 ISO Abbreviation: Contraception Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Marie Stopes International Australia, PO Box 1635, Melbourne VIC 3001, Australia. Electronic address: Philip.Goldstone@mariestopes.org.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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