| Effectiveness of deferiprone in transfusion-independent beta-thalassemia/HbE patients. | |
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MedLine Citation:
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PMID: 21418744 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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<title/> Beta-thalassemia/HbE (beta-thal/HbE) is a thalassemia intermedia (TI) which encompasses a broad spectrum of severity. Here, we used deferiprone (DFP) as an iron chelating agent in TI patients receiving intermittent blood transfusion who are asymptomatic for cardiovascular disease in order to evaluate the effectiveness in iron overload and reduce the possibility of cardiovascular complications. Thirty transfusion-independent beta-thal/HbE patients with iron overload were treated with DFP for 1 year. Hematological, biochemical, oxidative stress and echocardiographic parameters were determined. Serum ferritin, non-transferrin-bound iron, and malondialdehyde decreased significantly (P<0·05) after 1-year treatment with DFP. For echocardiographic results, mean pulmonary arterial pressure and pulmonary vascular resistance were diminished significantly (P<0·05). All those parameters were still improved after subgroup analysis was done for the high ferritin group (>2500 ng/ml). DFP therapy alone improved iron overload and oxidative stress and compliance was good. We propose that prevention of pulmonary hypertension is also possible for TI undergoing intermittent blood transfusion. |
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Authors:
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Krittapoom Akrawinthawong; Nithima Chaowalit; Thanasaporn Chatuparisuth; Noppadol Siritanaratkul |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hematology (Amsterdam, Netherlands) Volume: 16 ISSN: 1607-8454 ISO Abbreviation: Hematology Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708388 Medline TA: Hematology Country: England |
Other Details:
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Languages: eng Pagination: 113-22 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Medicine, Department of Internal Medicine, Siriraj Hospital, Mahidol University, Thailand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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