Document Detail

Effectiveness of conservative management of acoustic neuromas.
MedLine Citation:
PMID:  11078076     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The goal of this study was to assess the effectiveness of the conservative management in patients with acoustic neuroma (vestibular schwannoma). STUDY DESIGN: This retrospective study was performed in a university hospital. PATIENTS: Patients were selected for this wait-and-see policy on the basis of age, general condition, audiometric results, tumor size, and patient preference. The study group included 97 patients, 87 of whom had at least two neuroradiologic examinations. The mean age of this population was 63 years (29 to 89 years). The mean length of follow-up of this population was 31 months. Eighty-seven of these patients had at least two radiologic examinations (magnetic resonance imaging or computed tomography). The mean interval between the initial and follow-up radiologic examinations was 15 months. MAIN OUTCOME MEASURES: Tumor size was measured by use of two-dimensional data in all patients. The mean tumor size was 12 mm. The growth rate of the tumor was estimated by comparison of the results of the measurements from the initial and follow-up neuroradiologic examinations. RESULTS: Of the 97 patients studied, 6 patients required surgery and 6 required radiotherapy. Sixty patients (62%) were still being treated conservatively at the end of the study period. Three patients of 28 who were classified as candidates for hearing preservation surgery lost their candidacy during the observation period. The mean annual tumor growth rate was 1.52 mm/year. The tumor was stable in size in 36% of patients, regressed in 11% of patients, or grew in 53% of patients. The growth patterns of the acoustic neuroma fell into five categories: continuous growth in 15% of patients, negative growth in 5%, growth followed by negative growth in 40%, negative growth followed by growth in 20%, and no variation of tumor size in 20%. CONCLUSION: Conservative management of acoustic neuromas carries difficulties: long-term follow-up of the patients and unpredictability of the tumor growth pattern. A reliable and reproducible radiologic method for evaluating tumor size is of great importance.
Y J Shin; B Fraysse; C Cognard; I Gafsi; J P Charlet; C Berges; O Deguine; M Tremoulet
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of otology     Volume:  21     ISSN:  0192-9763     ISO Abbreviation:  Am J Otol     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-04-05     Completed Date:  2001-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909513     Medline TA:  Am J Otol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  857-62     Citation Subset:  IM    
Department of Otolaryngology, Hôpital Purpan, Toulouse, France.
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MeSH Terms
Aged, 80 and over
Audiometry, Pure-Tone
Cochlear Nerve / pathology,  radiography,  surgery
Deafness / diagnosis,  etiology
Disease Progression
Follow-Up Studies
Gadolinium / diagnostic use
Magnetic Resonance Imaging
Middle Aged
Neoplasm Invasiveness
Neuroma, Acoustic / complications,  diagnosis,  therapy*
Reproducibility of Results
Retrospective Studies
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:

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