Document Detail

Effectiveness of combined administration of lithium carbonate and prednisolone in neutropenias
MedLine Citation:
PMID:  3931275     Owner:  NLM     Status:  MEDLINE    
Use was made of 3 schedules of the combined use of lithium carbonate and prednisolone in patients with neutropenias of different genesis. Prednisolone was used in a single dose on day 10 of lithium carbonate intake (1), prednisolone was included into lithium carbonate therapy (2), and lithium carbonate was included into prednisolone therapy (3). The effect attained with the combined use of prednisolone and lithium carbonate appeared higher as compared to that with the use of each drug alone. The data obtained point to the differences between lithium carbonate and prednisolone if viewed from the standpoint of the mechanism of the neutropoiesis-stimulating action. It is recommended that lithium carbonate (0.3 g thrice a day) may be combined with prednisolone (0.4 mg/kg bw a day). The latter drug should be included into the treatment schedule since the 4th day of lithium therapy for neutropenias of different genesis including those caused by cytostatic treatment and irradiation.
L L Iavorkovskiĭ; L I Iavorkovskiĭ
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Terapevticheskiĭ arkhiv     Volume:  57     ISSN:  0040-3660     ISO Abbreviation:  Ter. Arkh.     Publication Date:  1985  
Date Detail:
Created Date:  1985-11-12     Completed Date:  1985-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984818R     Medline TA:  Ter Arkh     Country:  USSR    
Other Details:
Languages:  rus     Pagination:  84-8     Citation Subset:  IM    
Vernacular Title:
Effektivnost' sochetannogo primeneniia karbonata litiia i prednizolona pri neĭtropeniiakh.
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MeSH Terms
Agranulocytosis / drug therapy*
Drug Administration Schedule
Drug Synergism
Drug Therapy, Combination
Leukocyte Count / drug effects
Lithium / administration & dosage*
Lithium Carbonate
Middle Aged
Neutropenia / drug therapy*
Prednisolone / administration & dosage*
Reg. No./Substance:
50-24-8/Prednisolone; 554-13-2/Lithium Carbonate; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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