Document Detail


Effectiveness of cinacalcet in patients with recurrent/persistent secondary hyperparathyroidism following parathyroidectomy: results of the ECHO study.
MedLine Citation:
PMID:  20947534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Progressive secondary hyperparathyroidism (sHPT) is characterized by parathyroid gland hyperplasia which may ultimately require parathyroidectomy (PTX). Although PTX is generally a successful treatment for those patients subjected to surgery, a significant proportion develops recurrent sHPT following PTX. ECHO was a pan-European observational study which evaluated the achievement of KDOQI(TM) treatment targets with cinacalcet use in patients on dialysis. Previously published results showed that cinacalcet plus flexible vitamin D therapy lowered serum PTH, phosphorus and calcium in the clinical practice with similar efficacy as seen in phase III trials.
METHODS: This subgroup analysis of ECHO describes the real-world cinacalcet treatment effect in patients with recurrent or persistent sHPT after PTX (n = 153) compared to sHPT patients without prior history of PTX (n = 1696).
RESULTS: Both groups of patients had substantially elevated serum PTH with comparable sHPT severity at baseline. After 12 months of cinacalcet treatment, 20.3% (26/128) of patients with prior PTX and 18.2% (253/1388) of patients without prior PTX achieved serum PTH and Ca × P values within the recommended KDOQI(TM) target ranges.
CONCLUSIONS: Our data support the successful use of cinacalcet in patients with recurrent/persistent sHPT after PTX.
Authors:
Emanuel Zitt; Marianne Rix; Pablo Ureña Torres; Denis Fouque; Stefan H Jacobson; Frank Pétavy; Bastian Dehmel; Miroslav Ryba
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Publication Detail:
Type:  Journal Article     Date:  2010-10-14
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  26     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-06     Completed Date:  2011-09-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  1956-61     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Dialysis, Academic Teaching Hospital Feldkirch, Feldkirch, Austria. Emanuel.Zitt@lkhf.at
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MeSH Terms
Descriptor/Qualifier:
Aged
Calcium / blood
Cohort Studies
Female
Follow-Up Studies
Humans
Hyperparathyroidism, Secondary / drug therapy*,  etiology*
Kidney Failure, Chronic / complications*,  therapy
Male
Middle Aged
Naphthalenes / therapeutic use*
Parathyroid Hormone / blood
Parathyroidectomy / adverse effects*
Phosphorus / blood
Recurrence
Renal Dialysis
Survival Rate
Treatment Outcome
Vitamin D / administration & dosage
Chemical
Reg. No./Substance:
0/Naphthalenes; 0/Parathyroid Hormone; 1406-16-2/Vitamin D; 7440-70-2/Calcium; 7723-14-0/Phosphorus; UAZ6V7728S/cinacalcet

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