| Effectiveness of cinacalcet in patients with recurrent/persistent secondary hyperparathyroidism following parathyroidectomy: results of the ECHO study. | |
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MedLine Citation:
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PMID: 20947534 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background. Progressive secondary hyperparathyroidism (sHPT) is characterized by parathyroid gland hyperplasia which may ultimately require parathyroidectomy (PTX). Although PTX is generally a successful treatment for those patients subjected to surgery, a significant proportion develops recurrent sHPT following PTX. ECHO was a pan-European observational study which evaluated the achievement of KDOQI(TM) treatment targets with cinacalcet use in patients on dialysis. Previously published results showed that cinacalcet plus flexible vitamin D therapy lowered serum PTH, phosphorus and calcium in the clinical practice with similar efficacy as seen in phase III trials. Methods. This subgroup analysis of ECHO describes the real-world cinacalcet treatment effect in patients with recurrent or persistent sHPT after PTX (n = 153) compared to sHPT patients without prior history of PTX (n = 1696). Results. Both groups of patients had substantially elevated serum PTH with comparable sHPT severity at baseline. After 12 months of cinacalcet treatment, 20.3% (26/128) of patients with prior PTX and 18.2% (253/1388) of patients without prior PTX achieved serum PTH and Ca × P values within the recommended KDOQI(TM) target ranges. Conclusions. Our data support the successful use of cinacalcet in patients with recurrent/persistent sHPT after PTX. |
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Authors:
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Emanuel Zitt; Marianne Rix; Pablo Ureña Torres; Denis Fouque; Stefan H Jacobson; Frank Pétavy; Bastian Dehmel; Miroslav Ryba |
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Publication Detail:
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Type: Journal Article Date: 2010-10-14 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 1956-61 Citation Subset: IM |
Affiliation:
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Correspondence and offprint requests to: Emanuel Zitt; E-mail: Emanuel.Zitt@lkhf.at. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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