Document Detail

Effectiveness of carvedilol for congestive heart failure that developed long after modified Fontan operation.
MedLine Citation:
PMID:  16841268     Owner:  NLM     Status:  MEDLINE    
We report a case of a patient with severe heart failure after Fontan procedure in whom carvedilol was very effective. A 27-year-old man had intractable congestive heart failure due to severe ventricular dysfunction after Fontan operation. Central venous pressure was elevated to 29 mmHg. A right-to-left shunt was noted across a large collateral vessel between the innominate vein and the pulmonary vein. He was administered carvedilol (initial dose, 2 mg/day; maximum dose, 30 mg/day). Cardiac catheterization performed 1 year after carvedilol administration revealed a decrease in atrial pressure and improvement of ventricular function. He underwent a conversion operation to total cavopulmonary connection (TCPC) and ligation of a collateral vein communicating with the innominate and pulmonary veins. Carvedilol may be a legitimate treatment before TCPC conversion or heart transplantation for the high-risk group of patients with a failed Fontan circulation.
Naoko Ishibashi; In-Sam Park; Yukiko Takahashi; Mitsunori Nishiyama; Yasue Murakami; Katsuhiko Mori; Shigekazu Mimori; Makoto Ando; Yukihiro Takahashi; Toshio Nakanishi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-07-13
Journal Detail:
Title:  Pediatric cardiology     Volume:  27     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-08-11     Completed Date:  2007-02-13     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-5     Citation Subset:  IM    
Department of Pediatrics and Cardiovascular Surgery, Sakakibara Heart Institute, Asahi-machi 3-16-1, Fuchu-shi, Tokyo, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Carbazoles / therapeutic use*
Embolization, Therapeutic
Fontan Procedure / adverse effects*
Heart Bypass, Right
Heart Failure / drug therapy*,  etiology
Heart Septal Defects, Ventricular / surgery
Mitral Valve / abnormalities,  surgery
Propanolamines / therapeutic use*
Pulmonary Valve Stenosis / surgery
Transposition of Great Vessels / surgery
Ventricular Dysfunction / complications,  therapy
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol

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