Document Detail

Effectiveness of benzathine penicillin regimen in the treatment of syphilis in pregnancy.
MedLine Citation:
PMID:  2738484     Owner:  NLM     Status:  MEDLINE    
The intramuscular injection of benzathine penicillin G 2.4 million units weekly for 3 consecutive weeks to syphilitic pregnant women was again confirmed to be clinically effective for prevention of their neonates from congenital syphilis and well accepted as treatment for syphilis in pregnancy. It was administered to 184 cases, or 93.5 per cent, of 197 syphilitic gravidas. It was found that pregnancy outcomes in terms of abortion, stillbirth, prematurity, full term delivery, neonatal birth weight, macroscopic examination of the placenta and general physical examination of the neonate were clinically useful as a parameter to evaluate the effectiveness of the therapy for the infant. Clinical symptoms and signs in the mother, serological tests for syphilis in the gravida and cord blood of the newborn, and placental weight were not useful in the evaluation of adequacy of treatment of our study group.
S Phaosavasdi; W Snidvongs; P Thasanapradit; P Ungthavorn; S Bhongsvej; S Jongpiputvanich; S Vesjajiva; P Udomsantisuk; A Chitwarakorn; K Panikabutra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  72     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-07-28     Completed Date:  1989-07-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  101-8     Citation Subset:  IM    
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MeSH Terms
Infant, Newborn
Penicillin G / therapeutic use*
Penicillin G Benzathine / therapeutic use*
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Outcome
Syphilis / drug therapy*
Syphilis, Congenital / prevention & control*
Reg. No./Substance:
1538-09-6/Penicillin G Benzathine; 61-33-6/Penicillin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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