Document Detail

Effectiveness of azathioprine treatment in multiple sclerosis.
MedLine Citation:
PMID:  3403219     Owner:  NLM     Status:  MEDLINE    
As the effectiveness of continuous azathioprine therapy in multiple sclerosis (MS) is still controversial, we have conducted a prospective trial of the drug (2 mg/kg daily for at least 2 years) in patients with clinically definite MS, ie with remitting, remitting-progressive and progressive MS. At the end of an average 3-year follow-up 65% of the 40 patients with remitting-progressive had the same EDSS score as they had to start with. This was observed mainly in patients with longstanding MS and a high baseline EDSS. Of the 22 patients with a remitting course 77% showed no clinical deterioration and the annual relapse rate declined, although not significantly. In only one case did the remitting disease become remitting-progressive. Azathioprine would seem to have some efficacy in delaying the progression of remitting MS.
L Fratiglioni; G F Siracusa; M P Amato; D Sità; L Amaducci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of neurological sciences     Volume:  9     ISSN:  0392-0461     ISO Abbreviation:  Ital J Neurol Sci     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-15     Completed Date:  1988-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006502     Medline TA:  Ital J Neurol Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  261-4     Citation Subset:  IM    
Clinica Neurologica Ia, Università degli Studi di Firenze.
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MeSH Terms
Azathioprine / adverse effects,  therapeutic use*
Follow-Up Studies
Middle Aged
Multiple Sclerosis / drug therapy*
Reg. No./Substance:

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