| Effectiveness of atenolol in the treatment of hypertension during pregnancy. | |
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MedLine Citation:
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PMID: 1735566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study assessed the effectiveness of atenolol in the treatment of moderate and severe hypertension during pregnancy. Seventy patients (mean age, 30.3 +/- 6.0 years), 35.7% primiparous, were included. Three groups were formed according to Davey and MacGillivray's classification: 1) chronic hypertension without proteinuria (12 patients), 2) gestational hypertension without proteinuria (52 patients), and 3) preeclampsia (six patients). Treatment with atenolol was started when blood pressure was 150/100 mm Hg or higher after 48 hours' rest. The treatment lasted at least 1 week; follow-up was every 2 weeks up to week 36, and from then on, weekly up to delivery. If blood pressure exceeded 160/110 mm Hg and the fetus was not yet mature, a second drug was added. A significant decrease in blood pressure was observed in the three groups (group 1: 155.8 +/- 15.0/100.8 +/- 7.6 versus 135.0 +/- 12.9/85.0 +/- 6.7 mm Hg; group 2: 154.2 +/- 13.6/104.9 +/- 9.3 versus 129.6 +/- 10.2/83.7 +/- 9.1 mm Hg; group 3: 158.3 +/- 27.1/104.1 +/- 8.0 versus 129.1 +/- 6.6/87.5 +/- 6.1 mm Hg). The doses of atenolol were 62.5 +/- 23.0 mg/day in group 1, 70.0 +/- 30.0 mg/day in group 2, and 100.0 +/- 41.0 mg/day in group 3. There was no fetal mortality. No significant difference occurred in newborn body weights. Four babies from group 2 mothers had an Apgar score of less than 7 at 1 minute, but only one remained abnormal after 5 minutes. In the same group, three cases of respiratory distress were observed.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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G Fabregues; L Alvarez; P Varas Juri; S Drisaldi; C Cerrato; C Moschettoni; D Pituelo; H P Baglivo; R J Esper |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Hypertension Volume: 19 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-06 Completed Date: 1992-03-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: II129-31 Citation Subset: IM |
Affiliation:
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Cardiology Division, Policlinica Bancaria, Buenos Aires, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atenolol / therapeutic use* Female Humans Hypertension / drug therapy* Parity Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* |
| Chemical | |
Reg. No./Substance:
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29122-68-7/Atenolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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