Document Detail

Effectiveness of aldose reductase inhibitors for diabetic gastroenteropathy with constipation.
MedLine Citation:
PMID:  9240496     Owner:  NLM     Status:  MEDLINE    
We present a diabetic patient with long-standing constipation complicated by paralytic ileus and septic shock. She successfully recovered from a critical condition, and her diabetes was well controlled. However, the constipation did not improve even after the administration of conventional medications. Epalrestat, an aldose reductase inhibitor (ARI), improved her bowel motility and autonomic cardiovascular dysfunction, as evident from her heart rate and blood pressure response. Gastroenteropathy is a major diabetic complication which may cause disturbed bowel motility leading to serious enterobacterial infections, thus, its amelioration is important. ARI may be beneficial in the treatment of diabetic gastroenteropathy refractory to conventional therapies.
T Nakamura; R Okano; H Uchiyama; Y Seo; S Okuda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  36     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-29     Completed Date:  1997-09-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  479-83     Citation Subset:  IM    
Department of Internal Medicine, Kumihama Municipal Hospital, Kumano-gun, Kyoto.
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MeSH Terms
Aldehyde Reductase / antagonists & inhibitors*,  physiology
Autonomic Nervous System Diseases / drug therapy*,  etiology
Cardiovascular Diseases / drug therapy,  etiology
Constipation / drug therapy*,  etiology
Diabetes Mellitus, Type 2 / complications*
Diabetic Neuropathies / complications*
Enzyme Inhibitors / pharmacology,  therapeutic use*
Gastrointestinal Motility / drug effects*
Hemodynamics / drug effects
Intestinal Pseudo-Obstruction / etiology
Middle Aged
Rhodanine / analogs & derivatives*,  pharmacology,  therapeutic use
Shock, Septic / etiology
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Thiazolidines; 141-84-4/Rhodanine; 82159-09-9/ONO 2235; EC Reductase

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