| Effectiveness of the adriamycin-DNA complex in kidney allograft immunosuppression. | |
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MedLine Citation:
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PMID: 7034915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The chemotherapeutic effectiveness of the lysosomotropic Adriamycin-DNA complex has been demonstrated experimentally. This study evaluated the immunosuppressive activity of the complex on renal allografts in rats of the Buffalo-Lewis strain. Six rats receiving no treatment served as a control. Five rats received DNA along (at a dose equivalent to that in the complex), seven received the Adriamycin-DNA complex (molar ratio of DNA mononucleotide to Adriamycin, 20:1) and five were given free Adriamycin. Adriamycin, free or linked to DNA, was injected as follows: 2 mg/kg on days 2, 6 and 9 and 1 mg/kg on day 13 after transplantation. The Adriamycin-DNA complex prevented renal allograft rejection in the early postoperative period, by delaying for more than a week, the increase in serum creatinine levels in animals receiving transplants. Histologic examination of renal grafts in these rats confirmed the reduced severity of acute cellular rejection. There was also functional and morphologic evidence of reduced toxicity of Adriamycin when linked to DNA. The beneficial effect of such a drug should be attributed to its lysosomotropic mechanism of activity. |
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Authors:
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C Smeesters; L Giroux; A Trouet; G Jean; F Boury; J Corman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of surgery. Journal canadien de chirurgie Volume: 24 ISSN: 0008-428X ISO Abbreviation: Can J Surg Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-04-22 Completed Date: 1982-04-22 Revised Date: 2007-08-16 |
Medline Journal Info:
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Nlm Unique ID: 0372715 Medline TA: Can J Surg Country: CANADA |
Other Details:
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Languages: eng Pagination: 597-600 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Creatinine / blood DNA / pharmacology* DNA Adducts* Doxorubicin / pharmacology* Drug Combinations / pharmacology Graft Rejection / drug effects* Immunosuppressive Agents* Kidney / drug effects, physiopathology Kidney Transplantation* Male Rats Rats, Inbred BUF Rats, Inbred Lew |
| Chemical | |
Reg. No./Substance:
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0/DNA Adducts; 0/Drug Combinations; 0/Immunosuppressive Agents; 0/doxorubicin-DNA; 23214-92-8/Doxorubicin; 60-27-5/Creatinine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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