Document Detail


Effectiveness of the adriamycin-DNA complex in kidney allograft immunosuppression.
MedLine Citation:
PMID:  7034915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chemotherapeutic effectiveness of the lysosomotropic Adriamycin-DNA complex has been demonstrated experimentally. This study evaluated the immunosuppressive activity of the complex on renal allografts in rats of the Buffalo-Lewis strain. Six rats receiving no treatment served as a control. Five rats received DNA along (at a dose equivalent to that in the complex), seven received the Adriamycin-DNA complex (molar ratio of DNA mononucleotide to Adriamycin, 20:1) and five were given free Adriamycin. Adriamycin, free or linked to DNA, was injected as follows: 2 mg/kg on days 2, 6 and 9 and 1 mg/kg on day 13 after transplantation. The Adriamycin-DNA complex prevented renal allograft rejection in the early postoperative period, by delaying for more than a week, the increase in serum creatinine levels in animals receiving transplants. Histologic examination of renal grafts in these rats confirmed the reduced severity of acute cellular rejection. There was also functional and morphologic evidence of reduced toxicity of Adriamycin when linked to DNA. The beneficial effect of such a drug should be attributed to its lysosomotropic mechanism of activity.
Authors:
C Smeesters; L Giroux; A Trouet; G Jean; F Boury; J Corman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of surgery. Journal canadien de chirurgie     Volume:  24     ISSN:  0008-428X     ISO Abbreviation:  Can J Surg     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2007-08-16    
Medline Journal Info:
Nlm Unique ID:  0372715     Medline TA:  Can J Surg     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  597-600     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Creatinine / blood
DNA / pharmacology*
DNA Adducts*
Doxorubicin / pharmacology*
Drug Combinations / pharmacology
Graft Rejection / drug effects*
Immunosuppressive Agents*
Kidney / drug effects,  physiopathology
Kidney Transplantation*
Male
Rats
Rats, Inbred BUF
Rats, Inbred Lew
Chemical
Reg. No./Substance:
0/DNA Adducts; 0/Drug Combinations; 0/Immunosuppressive Agents; 0/doxorubicin-DNA; 23214-92-8/Doxorubicin; 60-27-5/Creatinine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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