| Effectiveness, active energy produced by molecular motors, and nonlinear capacitance of the cochlear outer hair cell. | |
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MedLine Citation:
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PMID: 16060346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cochlear outer hair cells are crucial for active hearing. These cells have a unique form of motility, named electromotility, whose main features are the cell's length changes, active force production, and nonlinear capacitance. The molecular motor, prestin, that drives outer hair cell electromotility has recently been identified. We reveal relationships between the active energy produced by the outer hair cell molecular motors, motor effectiveness, and the capacitive properties of the cell membrane. We quantitatively characterize these relationships by introducing three characteristics: effective capacitance, zero-strain capacitance, and zero-resultant capacitance. We show that zero-strain capacitance is smaller than zero-resultant capacitance, and that the effective capacitance is between the two. It was also found that the differences between the introduced capacitive characteristics can be expressed in terms of the active energy produced by the cell's molecular motors. The effectiveness of the cell and its molecular motors is introduced as the ratio of the motors'active energy to the energy of the externally applied electric field. It is shown that the effectiveness is proportional to the difference between zero-strain and zero-resultant capacitance. We analyze the cell and motor's effectiveness within a broad range of cellular parameters and estimate it to be within a range of 12%-30%. |
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Authors:
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Alexander A Spector |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomechanical engineering Volume: 127 ISSN: 0148-0731 ISO Abbreviation: J Biomech Eng Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-08-02 Completed Date: 2005-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909584 Medline TA: J Biomech Eng Country: United States |
Other Details:
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Languages: eng Pagination: 391-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland avenue, Traylor 411, Baltimore, Maryland 21205, USA. aspector@bme.jhu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Computer Simulation Elasticity Electric Capacitance Energy Transfer / physiology*, radiation effects Hair Cells, Auditory, Outer / physiology*, radiation effects Humans Mechanotransduction, Cellular / physiology*, radiation effects Membrane Potentials / physiology*, radiation effects Models, Biological* Molecular Motor Proteins / physiology*, radiation effects Movement / physiology, radiation effects Nonlinear Dynamics |
| Chemical | |
Reg. No./Substance:
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0/Molecular Motor Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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