Document Detail

Effectiveness and acceptability of vitamin E and low-dose aspirin, alone or in combination, on Norplant-induced prolonged bleeding.
MedLine Citation:
PMID:  15541406     Owner:  NLM     Status:  MEDLINE    
A study (ISRCTN 77665712) was undertaken to test the effectiveness and the acceptability of vitamin E and low-dose aspirin, alone or in combination, as treatment for prolonged vaginal bleeding induced by Norplant. A total of 486 Norplant users who were requesting treatment for bleeding lasting longer than 7 days were enrolled in five centers: Beijing, China; Jakarta, Indonesia; Santiago, Chile; Santo Domingo, Dominican Republic; and Tunis, Tunisia. They were randomized to one of four different 10-day oral treatments: 200 mg vitamin E daily, 80 mg aspirin daily, both or a placebo. Treatment packs were designed to ensure blinding of both the subjects and the clinical staff. Neither vitamin E nor low-dose aspirin nor their combination was found to have any effect on reducing the length of the bleeding episode for which treatment was taken or on the vaginal bleeding patterns these women experienced during the year of follow-up.
Catherine d'Arcangues; Gilda Piaggio; Vivian Brache; Rim Ben Aissa; Catherine Hazelden; Rebeca Massai; Alain Pinol; Sri Bekti Subakir; Gu Su-juan;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Contraception     Volume:  70     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2005-04-22     Revised Date:  2006-06-02    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  451-62     Citation Subset:  IM    
Special Programme of Research, World Health Organization, Development and Research Training in Human Reproduction (HRP), CH-1211-Geneva-27, Switzerland.
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MeSH Terms
Administration, Oral
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Aspirin / administration & dosage*
Dominican Republic
Drug Administration Schedule
Levonorgestrel / adverse effects*
Patient Satisfaction
Treatment Outcome
Uterine Hemorrhage / chemically induced,  drug therapy*
Vitamin E / administration & dosage*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 1406-18-4/Vitamin E; 50-78-2/Aspirin; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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