| Effectiveness of Various Anthelmintics in the Treatment of Moniliformiasis in Experimentally Infected Wistar Rats. | |
| | |
MedLine Citation:
|
PMID: 21254932 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Humans occasionally become infected with acanthocephalans, particularly Moniliformis moniliformis. Although several anthelmintics have been used, no controlled studies have been conducted to assess the efficacy of common anthelmintics in the treatment of moniliformiasis. The effectiveness of pyrantel pamoate, ivermectin, praziquantel, niclosamide, thiabendazole, and mebendazole was evaluated in the treatment of moniliformiasis in laboratory-infected female Wistar rats. Pyrantel pamoate and ivermectin were wholly unsuccessful in the treatment of moniliformiasis. A single dose of thiabendazole lead to a 40% reduction and two doses lead to a 57% reduction of worm burden after 2 weeks. The most effective drug in the treatment of moniliformiasis in rats was mebendazole, for which two doses resulted in a 69% reduction in worm burden after 2 weeks; however, 50% of the rats receiving the treatment died within 2 weeks after first administration of the drug. Two surviving rats that had been treated with mebendazole exhibited evidence of hepatic dysfunction characterized by extremely elevated levels of alkaline phosphatase in conjuction with depressed serum albumin levels. It is hypothesized that Mo. moniliformis may metabolize the drug and release a metabolite that is highly toxic to the host. On the basis of these data, thiabendazole is recommended as the drug of choice for the treatment of human acanthocephaliasis until more extensive testing can be conducted. |
| | |
Authors:
|
Dennis J Richardson; Cheryl D Brink |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-23 |
Journal Detail:
|
Title: Vector borne and zoonotic diseases (Larchmont, N.Y.) Volume: - ISSN: 1557-7759 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100965525 Medline TA: Vector Borne Zoonotic Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Biological Sciences, Quinnipiac University , Hamden, Connecticut. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mutation Studies in the CFTR Gene in Asian Indian Subjects with Congenital Bilateral Absence of Vas ...
Next Document: Hand-Assisted Laparoscopic Radical Nephrectomy.