Document Detail


Effectiveness of seasonal influenza vaccines in the United States during a season with circulation of all three vaccine strains.
MedLine Citation:
PMID:  22843783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Influenza vaccines may be reformulated annually because of antigenic drift in influenza viruses. However, the relationship between antigenic characteristics of circulating viruses and vaccine effectiveness (VE) is not well understood. We conducted an assessment of the effectiveness of US influenza vaccines during the 2010-2011 season.
METHODS: We performed a case-control study comparing vaccination histories between subjects with acute respiratory illness with positive real-time reverse transcription polymerase chain reaction for influenza and influenza test-negative controls. Subjects with acute respiratory illness of ≤7 days duration were enrolled in hospitals, emergency departments, or outpatient clinics in communities in 4 states. History of immunization with the 2010-2011 vaccine was ascertained from vaccine registries or medical records. Vaccine effectiveness was estimated in logistic regression models adjusted for study community, age, race, insurance status, enrollment site, and presence of a high-risk medical condition.
RESULTS: A total of 1040 influenza-positive cases and 3717 influenza-negative controls were included from the influenza season, including 373 cases of influenza A(H1N1), 334 cases of influenza A(H3N2), and 333 cases of influenza B. Overall adjusted VE was 60% (95% confidence interval [CI], 53%-66%). Age-specific VE estimates ranged from 69% (95% CI, 56%-77%) in children aged 6 months-8 years to 38% (95% CI, -16% to 67%) in adults aged ≥65 years.
CONCLUSIONS: The US 2010-2011 influenza vaccines were moderately effective in preventing medically attended influenza during a season when all 3 vaccine strains were antigenically similar to circulating viruses. Continued monitoring of influenza vaccines in all age groups is important, particularly as new vaccines are introduced.
Authors:
John J Treanor; H Keipp Talbot; Suzanne E Ohmit; Laura A Coleman; Mark G Thompson; Po-Yung Cheng; Joshua G Petrie; Geraldine Lofthus; Jennifer K Meece; John V Williams; Lashondra Berman; Caroline Breese Hall; Arnold S Monto; Marie R Griffin; Edward Belongia; David K Shay;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2012-07-25
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  55     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-10     Completed Date:  2013-01-23     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  951-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Rochester Medical Center, NY, USA. john_treanor@urmc.rochester.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Child
Child, Preschool
Female
Humans
Infant
Influenza Vaccines / administration & dosage,  immunology*
Influenza, Human / epidemiology*,  prevention & control*
Male
Middle Aged
Treatment Outcome
United States / epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
1K23AI074863-01/AI/NIAID NIH HHS; U01 IP000170/IP/NCIRD CDC HHS; U01 IP000172/IP/NCIRD CDC HHS; U01 IP000183/IP/NCIRD CDC HHS
Chemical
Reg. No./Substance:
0/Influenza Vaccines
Investigator
Investigator/Affiliation:
J Donahue / ; S Irving / ; B Kieke / ; S Kjos / ; S Koptizke / ; P Squires / ; M Vandermause / ; S Waring / ; L Blythe / ; R Cross / ; E Johnson / ; M Zervos / ; L Lamerato / ; A Falsey / ; B-K Yoo / ; N Bennett / ; P Szylagyi / ; K Schnabel / ; K Edwards / ; Y Zhu / ; D Wyatt / ; D Kent / ; Z Liu / ; A Storrow / ; L Laya / ; P McNabb / ; S VanHook / ; S Lindstrom / ; X Xian / ; A Klimov / ; S Sambhara / ; J Katz / ; N Cox /
Comments/Corrections

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