Document Detail


Effectiveness of MI Paste Plus and PreviDent fluoride varnish for treatment of white spot lesions: a randomized controlled trial.
MedLine Citation:
PMID:  23273358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: White spot lesions are a common sequela of orthodontic therapy. In this parallel-group randomized trial, we assessed the effectiveness of 2 agents commonly used to ameliorate white spot lesions compared with a normal home-care regimen.
METHODS: Patients aged 12 to 20 years were recruited from the offices of orthodontists and dentists who belonged to the Practice-based Research Collaborative in Evidence-based Dentistry network. The patients had their orthodontic appliances removed within the past 2 months and had at least 1 white spot lesion affecting their maxillary incisors. The subjects were randomized to 1 of 3 arms: (1) an 8-week regimen of MI Paste Plus (GC America, Alsip, Ill), (2) a single application of PreviDent fluoride varnish (Colgate Oral Pharmaceuticals, New York, NY), and (3) usual home care (control). Photographs were taken at enrollment and 8 weeks later. Two panels consisting of 5 dental professionals and 5 laypersons assessed the before-and-after pairs of photographs in a blinded fashion. Objective assessments and self-assessments were also performed.
RESULTS: One hundred fifteen subjects completed the study; 34 were assigned to the MI Paste Plus group, 40 to the fluoride varnish group, and 41 to the control group. The mean improvements assessed by the professional panel were 21%, 29%, and 27% in the MI Paste Plus, fluoride varnish, and control groups, respectively.The results from the lay panel were 29%, 31%, and 25%, respectively. Objective improvements in the surface affected were 16%, 25%, and 17%, respectively; self-assessments of improvement were 37% in all 3 groups. No assessments indicated significant differences between subjects in the active arms compared with the control arm.
CONCLUSIONS: MI Paste Plus and PreviDent fluoride varnish do not appear to be more effective than normal home care for improving the appearance of white spot lesions over an 8-week period.
Authors:
Greg J Huang; Brie Roloff-Chiang; Brian E Mills; Salma Shalchi; Charles Spiekerman; Anna M Korpak; Jeri L Starrett; Geoffrey M Greenlee; Ross J Drangsholt; Jack C Matunas
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  143     ISSN:  1097-6752     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-02-19     Revised Date:  2013-03-06    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-41     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.
Affiliation:
Professor and chair, Department of Orthodontics, University of Washington, Seattle, WA 98195-7446, USA. ghuang@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Cariostatic Agents / therapeutic use*
Caseins / administration & dosage*
Child, Preschool
Dental Caries / drug therapy*,  etiology
Drug Synergism
Female
Fluorides, Topical / therapeutic use*
Fluorine / administration & dosage*
Humans
Male
Ointments
Oral Hygiene
Orthodontic Appliances / adverse effects
Single-Blind Method
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
TL1 TR000422/TR/NCATS NIH HHS; UL1 TR000423/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Cariostatic Agents; 0/Caseins; 0/Fluorides, Topical; 0/Ointments; 0/casein phosphopeptide-amorphous calcium phosphate nanocomplex; 7782-41-4/Fluorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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