Document Detail


Effectiveness of ketorolac tromethamine in prevention of severe retinopathy of prematurity.
MedLine Citation:
PMID:  20873697     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: This study assessed the effectiveness of the use of ketorolac tromethamine to reduce retinopathy of prematurity (ROP) incidence and its progression to more severe forms.
METHODS: Forty-seven preterm newborn infants with a birth weight (BW) of 1,000 grams or less and/or a gestational age (GA) of 29 weeks or less were enrolled in the study when avascular retina zone I or ROP any stage were diagnosed at screening. Studied infants were randomized to receive ketorolac tromethamine ophthalmic solution in one eye and a drop of placebo in the other eye, until ROP requiring treatment or full retinal vascularization was diagnosed.
RESULTS: Only 2 newborn infants did not develop ROP. Among 45 newborn infants who developed ROP, 6 showed different ROP staging between the two eyes, 4 of which had a better outcome in the eye receiving ketorolac tromethamine. The differences between ROP stagings were not significant even when analyzed by GA and BW subgroups. No significant treatment-related side effects occurred.
CONCLUSION: This report suggests that ketorolac tromethamine ophthalmic solution cannot reduce the risk of developing severe ROP in preterm infants.
Authors:
Carmen Giannantonio; Patrizia Papacci; Velia Purcaro; Francesco Cota; Mikael Ghennet Tesfagabir; Fernando Molle; Domenico Lepore; Antonio Baldascino; Costantino Romagnoli
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Publication Detail:
Type:  Journal Article     Date:  2010-09-22
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  48     ISSN:  1938-2405     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-07-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Copyright Information:
Copyright 2011, SLACK Incorporated.
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