Document Detail


Effectiveness of endovascular embolization with a collagen-based embolic agent (Marsembol) in an animal model.
MedLine Citation:
PMID:  20685135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate in a porcine experimental model the effectiveness, tissue penetration, and histologic impact of renal artery embolization with a collagen-based nonadhesive embolic agent, marsembol.
MATERIALS AND METHODS: Fifteen pigs underwent embolization of one interlobular artery of the renal artery with collagen-resorcinol gel emulsified with Lipiodol and further polymerized with glutaraldehyde-formaldehyde mixture. Angiograms were obtained before, during, and after the procedure. Animals were euthanized at day 0 (n = 3), 1 week (n = 3), or 3 months (n = 7), and flat-panel three-dimensional rotational radiologic images of the kidneys were obtained. Arterial, medullary, and cortical samples were taken for histologic and scanning electron microscopic investigations.
RESULTS: Fifteen interlobular renal arteries were successfully embolized by delivering 1.7 mL + or - 0.2 of the embolic agent. All the embolized arteries remained occluded at 3 months, leading to a major atrophy of the embolized portions of the kidneys. Imaging and histologic findings show that the embolic agent provided a distal vessel occlusion and entirely filled the lumen of the arteries up to the glomerular tufts. The homogeneous plug formed by the embolic agent induces very few inflammatory responses. The regenerative tubular processes were arrested at 3 months.
CONCLUSIONS: The collagen-based embolic agent described here has the properties required to perform embolization. These specific properties lead to very distal vessel embolization. The embolic agent is effective at 3 months in renal embolization.
Authors:
Vincent Vidal; Pierre-Henri Rolland; Laurent Daniel; Guy Moulin; Jean-Michel Bartoli; Olivier Levrier
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Publication Detail:
Type:  Journal Article     Date:  2010-08-03
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  21     ISSN:  1535-7732     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1419-23     Citation Subset:  IM    
Copyright Information:
Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved.
Affiliation:
School of Medicine, Laboratory of Physiopathology and Vascular Therapeutics, Hôpital La Timone, 27 boulevard Jean Moulin, 13385 Marseille cedex 5, France. vincent.vidal@ap-hm.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrophy
Collagen / administration & dosage*,  chemistry
Drug Combinations
Embolization, Therapeutic / methods*
Ethiodized Oil / administration & dosage
Formaldehyde / administration & dosage*
Gelatin / administration & dosage*
Gels
Glutaral / administration & dosage*
Imaging, Three-Dimensional
Kidney / blood supply*,  radiography,  ultrastructure
Microscopy, Electron, Scanning
Models, Animal
Renal Artery* / radiography
Resorcinols / administration & dosage*
Swine
Time Factors
Tissue Adhesives / administration & dosage*
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Gels; 0/Resorcinols; 0/Tissue Adhesives; 0/gelatin-resorcin-formaldehyde-glutaraldehyde adhesive; 111-30-8/Glutaral; 50-00-0/Formaldehyde; 8008-53-5/Ethiodized Oil; 9000-70-8/Gelatin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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