| Effectiveness of endovascular embolization with a collagen-based embolic agent (Marsembol) in an animal model. | |
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MedLine Citation:
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PMID: 20685135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate in a porcine experimental model the effectiveness, tissue penetration, and histologic impact of renal artery embolization with a collagen-based nonadhesive embolic agent, marsembol. MATERIALS AND METHODS: Fifteen pigs underwent embolization of one interlobular artery of the renal artery with collagen-resorcinol gel emulsified with Lipiodol and further polymerized with glutaraldehyde-formaldehyde mixture. Angiograms were obtained before, during, and after the procedure. Animals were euthanized at day 0 (n = 3), 1 week (n = 3), or 3 months (n = 7), and flat-panel three-dimensional rotational radiologic images of the kidneys were obtained. Arterial, medullary, and cortical samples were taken for histologic and scanning electron microscopic investigations. RESULTS: Fifteen interlobular renal arteries were successfully embolized by delivering 1.7 mL + or - 0.2 of the embolic agent. All the embolized arteries remained occluded at 3 months, leading to a major atrophy of the embolized portions of the kidneys. Imaging and histologic findings show that the embolic agent provided a distal vessel occlusion and entirely filled the lumen of the arteries up to the glomerular tufts. The homogeneous plug formed by the embolic agent induces very few inflammatory responses. The regenerative tubular processes were arrested at 3 months. CONCLUSIONS: The collagen-based embolic agent described here has the properties required to perform embolization. These specific properties lead to very distal vessel embolization. The embolic agent is effective at 3 months in renal embolization. |
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Authors:
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Vincent Vidal; Pierre-Henri Rolland; Laurent Daniel; Guy Moulin; Jean-Michel Bartoli; Olivier Levrier |
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Publication Detail:
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Type: Journal Article Date: 2010-08-03 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 21 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 1419-23 Citation Subset: IM |
Copyright Information:
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Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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School of Medicine, Laboratory of Physiopathology and Vascular Therapeutics, Hôpital La Timone, 27 boulevard Jean Moulin, 13385 Marseille cedex 5, France. vincent.vidal@ap-hm.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrophy Collagen / administration & dosage*, chemistry Drug Combinations Embolization, Therapeutic / methods* Ethiodized Oil / administration & dosage Formaldehyde / administration & dosage* Gelatin / administration & dosage* Gels Glutaral / administration & dosage* Imaging, Three-Dimensional Kidney / blood supply*, radiography, ultrastructure Microscopy, Electron, Scanning Models, Animal Renal Artery* / radiography Resorcinols / administration & dosage* Swine Time Factors Tissue Adhesives / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Gels; 0/Resorcinols; 0/Tissue Adhesives; 0/gelatin-resorcin-formaldehyde-glutaraldehyde adhesive; 111-30-8/Glutaral; 50-00-0/Formaldehyde; 8008-53-5/Ethiodized Oil; 9000-70-8/Gelatin; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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