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Effective high-dose chemotherapy combined with CD34+-selected autologous peripheral blood stem cell transplantation in a patient with cutaneous CD30-negative large T cell lymphoma.
MedLine Citation:
PMID:  10871740     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Generalized multiple cutaneous tumors developed in a 60-year-old Japanese man. Skin biopsy revealed atypical large T lymphocytes infiltrating the dermis. CD30 staining was negative in the tumor cells. The diagnosis of CD30-negative cutaneous large T cell lymphoma was made. Axial and inguinal lymphadenopathy was present, but there was no evidence of bone marrow involvement. Seven cycles of chemotherapy and local electron beam irradiation were administered and complete remission (CR) was attained. As CD30-negative cutaneous large T cell lymphoma has a poor prognosis despite intensive chemotherapy, high-dose chemotherapy followed by CD34+-selected autologous peripheral blood stem cell transplantation (CD34+-APBSCT) was prescribed. The clinical course after CD34+-selected APBSCT was complicated with CMV infection occurring twice but administration of ganciclovir resolved the symptoms. He has remained in CR for 16 months after CD34+-APBSCT. This appears to be the first case report of CD34+-APBSCT in a patient with CD30-negative cutaneous large T cell lymphoma. Bone Marrow Transplantation (2000) 25, 1315-1317.
Authors:
M Nishio; K Koizumi; T Endo; H Takashima; Y Haseyama; K Fujimoto; S Yamamoto; H Kobayashi; T Koike; K Sawada
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  25     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-21     Completed Date:  2000-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1315-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine II, Hokkaido University, School of Medicine, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD30
Antigens, CD34
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Combined Modality Therapy
Hematopoietic Stem Cell Transplantation*
Humans
Lymphoma, T-Cell, Cutaneous / pathology,  therapy*
Male
Middle Aged
Transplantation, Autologous
Chemical
Reg. No./Substance:
0/Antigens, CD30; 0/Antigens, CD34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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