Document Detail


Effective half life of iodine for five thyroidectomy patients using an in vivo gamma camera approach.
MedLine Citation:
PMID:  17971626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effective half-life of radioactive iodine for (near) thyroidectomy patients was evaluated using an in vivo gamma camera approach. Five patients with post administered iodine for remnant ablation of thyroid were thoroughly scanned in vivo for one to four weeks. Derived data were analyzed in a MATLAB program to revise the ICRP recommended effective half-life and, thus, to offer a more reliable dose predication protocol from a health physics viewpoint. A quantitative index, AT (Agreement), was also introduced to specify the deviation between the actual measurement and the results fitted in MATLAB for each patient. The ATs were evaluated as 1.52 +/- 1.54 and 14.05 +/- 11.01 for the thyroid compartment and the remainder, re-spectively, indicating a slight discrepancy between the computed and practical results for the remainder. The actual effective half-life of iodine in the thyroid or the body fluid compartment shifted from 7.3d or 0.24 d to only 0.61 +/- 0.50 d or 0.49 +/- 0.23 d, respectively. Additionally, the integrated T(eff) for the remainder (both body fluid and whole body compartments) was still about 5.8d, since the body fluid and the whole body compartment was inseparable in real whole body scanning. The branching ratio from body fluid compartment to the thyroid and the excretion compartment also changed from 30% and 70% to 11.6 +/- 14.0% and 88.4 +/- 14.6%, respectively. The thyroid was the dominant compartment for a healthy person in the traditional biokinetic model. However, this dominant compartment was shifted to both thyroid and body fluid, based on analyses of the data following thyroidectomy, for the patients herein.
Authors:
Chien-Yi Chen; Pai-Jung Chang; Sheng-Pin Changlai; Lung-Kwang Pan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-30
Journal Detail:
Title:  Journal of radiation research     Volume:  48     ISSN:  0449-3060     ISO Abbreviation:  J. Radiat. Res.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-26     Completed Date:  2008-01-03     Revised Date:  2012-03-28    
Medline Journal Info:
Nlm Unique ID:  0376611     Medline TA:  J Radiat Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  485-93     Citation Subset:  IM    
Affiliation:
Department of Medical Imaging and Radiology Science Chung Shan Medical University, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Gamma Cameras*
Half-Life
Humans
Iodine Radioisotopes / administration & dosage*,  chemistry,  pharmacokinetics*
Male
Metabolic Clearance Rate
Middle Aged
Organ Specificity
Thyroid Gland / metabolism*
Thyroidectomy
Tissue Distribution
Whole-Body Counting / instrumentation,  methods*
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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