| Effective control of viral infections by the adaptive immune system requires assistance from innate immunity. | |
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MedLine Citation:
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PMID: 20923266 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Evaluation of: Nakayama Y, Plisch EH, Sullivan JM et al. Role of PKR and type I IFNs in viral control during primary and secondary infection. PLoS Pathog. 6(6), e1000966 (2010). During acute viral infections, innate antiviral immunity has been extensively studied for its ability to inhibit and/or control viral replication while priming the adaptive immune system. Recently, these processes have been studied for their role in assisting adaptive immunity to effectively clear or control viral rechallenge. The paper under evaluation introduces the concept that functional innate immune mechanisms such as dsRNA-activated protein kinase (PKR) and type I interferons are critical in controlling viral replication during secondary lymphocyte choriomeningitis virus infection. Elegant adoptive transfer studies revealed that during lymphocyte choriomeningitis virus secondary infections, dependence of viral control relied on expression of these innate factors in virally infected cells and not in adaptive immune T cells. Such findings illustrate that functional adaptive responses are less effective in providing protection against reinfections in the absence of innate mechanisms. This demonstrates the importance of intact innate mechanisms when considering effective vaccine strategies. |
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Authors:
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Nicole G Barra; Amy Gillgrass; Ali A Ashkar |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Expert review of vaccines Volume: 9 ISSN: 1744-8395 ISO Abbreviation: Expert Rev Vaccines Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-06 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155475 Medline TA: Expert Rev Vaccines Country: England |
Other Details:
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Languages: eng Pagination: 1143-7 Citation Subset: - |
Affiliation:
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Center for Gene Therapeutics and Institute for Infectious Disease Research, McMaster University – MDCL 4074, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada. |
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Comment On:
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PLoS Pathog. 2010;6(6):e1000966
[PMID:
20585572
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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