Document Detail


Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed-phase eluents.
MedLine Citation:
PMID:  17096378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[4]Heterohelicenium cations 1a-c adopt a twisted helical structure that renders them chiral. They are configurationally stable and their enantiomers have been resolved, for the first time, by HPLC on Chiralcel OD-RH and Chirobiotic TAG chiral stationary phases (CSPs). Chiral cations 1a-c have been resolved by HPLC using water-based eluents containing KPF(6) as additive. The elution order of the analyte enantiomers was determined by on-line CD detection, and was found to be opposite on the two CSPs. The effect of mobile phase composition and analyte structure on retention and enantioselectivity was investigated.
Authors:
Claudio Villani; Benoît Laleu; Pierre Mobian; Jérôme Lacour
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chirality     Volume:  19     ISSN:  0899-0042     ISO Abbreviation:  Chirality     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914261     Medline TA:  Chirality     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-6     Citation Subset:  IM    
Affiliation:
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università di Roma La Sapienza, Roma, Italy. claudio.villani@uniroma1.it
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid / methods
Circular Dichroism
Coloring Agents / chemistry,  isolation & purification*
Molecular Conformation
Polycyclic Compounds / chemistry,  isolation & purification*
Stereoisomerism
Chemical
Reg. No./Substance:
0/Coloring Agents; 0/Polycyclic Compounds; 0/helicenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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