Document Detail

Effective dosage and administration schedule of oral alendronate for non-nociceptive symptoms in rats with chronic constriction injury.
MedLine Citation:
PMID:  20514318     Owner:  NLM     Status:  MEDLINE    
We evaluated the efficacy of oral alendronate with different dosing regimens for non-nociceptive symptoms and osteoporosis in a sciatic nerve chronic constriction injury (CCI) model. Male Sprague-Dawley rats (n=60) were subdivided into sham control (SC) group and CCI groups, which were divided according to dosage and time of oral alendronate administration: no treatment (NT), low dosage early (LE), high dosage early (HE), low dosage late (LL) and high dosage late (HL). We measured the thickness and temperature of the hind paw, bone mineral density (BMD) of the tibia, along with tibia bone strength. On the 14th day post-CCI, the HE group showed significant reduction in thickness and temperature (P<0.001). On the 42nd day post-CCI, the HE group showed significant reduction in temperature compared to the NT group (P<0.001). Also, both HE and HL groups showed statistically significant increased tibia BMD (P<0.001), along with increase of tibia bone strength compared to the NT group. Based on these findings, early alendronate in high dosages is effective in the non-nociceptive symptoms; early and late alendronate in high dosages, are effective in preventing bone dystrophic changes in a CCI model.
Sun Im; Seong-Hoon Lim; Jong-In Lee; Young-Jin Ko; Joo Hyun Park; Bo-Young Hong; Geun-Young Park
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Publication Detail:
Type:  Journal Article     Date:  2010-05-25
Journal Detail:
Title:  Journal of Korean medical science     Volume:  25     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-09-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  938-44     Citation Subset:  IM    
Department of Rehabilitation Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.
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MeSH Terms
Administration, Oral
Alendronate / administration & dosage*,  therapeutic use
Bone Density / drug effects
Bone and Bones / metabolism
Complex Regional Pain Syndromes / drug therapy*
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Schedule
Rats, Sprague-Dawley
Sciatic Nerve / injuries
Reg. No./Substance:

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