| Effective Cytochrome P450 (CYP) Inhibitors Isolated from Tarragon (<i>Artemisia dracunculus</i>). | |
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MedLine Citation:
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PMID: 22738981 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, Artemisia dracunculus. Their structures were spectroscopically identified as 2E,4E-undeca-2,4-diene-8,10-diynoic acid isobutylamide (1) and 2E,4E-undeca-2,4-diene-8,10-diynoic acid piperidide (2). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC<inf>50</inf> values of 10.0 ± 1.3 µM for compound 1 and 3.3 ± 0.2 µM for compound 2, and exhibited mechanism-based inhibition. This is the first reported isolation of effective CYP inhibitors from tarragon (Artemisia dracunculus) purchased from a Japanese market. |
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Authors:
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Zeineb Brahmi; Tatsuya Katho; Rie Hatsumata; Asako Hiroi; Nami Miyakawa; Emi Yakou; Kouichi Sugaya; Jun-Ichi Onose; Naoki Abe |
Publication Detail:
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Type: Journal Article Date: 2012-05-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 76 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-06-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 1028-31 Citation Subset: IM |
Affiliation:
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Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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