Document Detail


Effective Cytochrome P450 (CYP) Inhibitors Isolated from Tarragon (<i>Artemisia dracunculus</i>).
MedLine Citation:
PMID:  22738981     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, Artemisia dracunculus. Their structures were spectroscopically identified as 2E,4E-undeca-2,4-diene-8,10-diynoic acid isobutylamide (1) and 2E,4E-undeca-2,4-diene-8,10-diynoic acid piperidide (2). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC<inf>50</inf> values of 10.0 ± 1.3 µM for compound 1 and 3.3 ± 0.2 µM for compound 2, and exhibited mechanism-based inhibition. This is the first reported isolation of effective CYP inhibitors from tarragon (Artemisia dracunculus) purchased from a Japanese market.
Authors:
Zeineb Brahmi; Tatsuya Katho; Rie Hatsumata; Asako Hiroi; Nami Miyakawa; Emi Yakou; Kouichi Sugaya; Jun-Ichi Onose; Naoki Abe
Publication Detail:
Type:  Journal Article     Date:  2012-05-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  76     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1028-31     Citation Subset:  IM    
Affiliation:
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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