Document Detail

Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus.
MedLine Citation:
PMID:  3586647     Owner:  NLM     Status:  MEDLINE    
A deficiency of vitamin B6 has been reported to enhance oestrogen responsiveness of the uterus in rats whereas zinc deficiency provokes a syndrome suggestive of a diminution in oestrogen sensitivity. In this study [3H]oestrogen uptake by the uterus was increased in rats deficient in either nutrient and the differences were additive in the dually deficient animals. The total number of oestrogen receptors per g tissue was unaffected by either nutrient but the proportion of the receptors recovered from the nuclear fraction increased from about 6 to 74% when both nutrients were withheld. The results are consistent with the hypothesis that both zinc and pyridoxal phosphate play important metabolic roles in end-organ responsiveness to oestrogen.
G E Bunce; M Vessal
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of steroid biochemistry     Volume:  26     ISSN:  0022-4731     ISO Abbreviation:  J. Steroid Biochem.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-07-02     Completed Date:  1987-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0260125     Medline TA:  J Steroid Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
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MeSH Terms
Body Weight
Estradiol / metabolism*
Pyridoxal Phosphate / blood
Rats, Inbred Strains
Receptors, Estrogen / metabolism*
Uterus / metabolism*
Vitamin B 6 Deficiency / metabolism*
Zinc / blood,  deficiency*
Reg. No./Substance:
0/Receptors, Estrogen; 50-28-2/Estradiol; 54-47-7/Pyridoxal Phosphate; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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