Document Detail

Effect of zinc intake on growth in infants: A meta-analysis.
MedLine Citation:
PMID:  25365524     Owner:  NLM     Status:  Publisher    
Abstract A systematic review and meta-analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on growth in infants. Out of 5500 studies identified through electronic searches and reference lists, 19 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on growth was considered in the overall meta-analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. From each select growth study, final measures of Weight, Length, Mid upper arm circumference (MUAC), Head circumference, Weight for age z-score (WAZ), Length for age z-score (LAZ) and Weight for Length z-score (WLZ) were assessed. Pooled β and 95% confidence interval (CI) were calculated. Additionally we carried out a sensitivity analysis. Zn intake was not associated to Weight, Length, MUAC, Head Circumference and LAZ in the pooled analyses. However, Zn intake had a positive and statistically effect on WAZ (β = 0.06; 95%CI 0.02 to 0.10) and WLZ (β = 0.05; 95%CI 0.01 to 0.08). The dose response relationship between Zn intake and these parameters indicated that a doubling of Zn intake increased WAZ and WLZ by approximately 4%. Substantial heterogeneity was present only in Length analyses. (I(2) = 45%; p = 0.03). Zn intake was positively associated with length values at short time (4 to 20 weeks) (β = 0.01; CI 95% 0 to 0.02) and at medium doses of Zn (4.1 to 8 mg/day) (β = 0.003; CI 95% 0 to 0.01). Nevertheless, the effect magnitude was small. Our results indicate that Zn intake increases growth parameters of infants. Nonetheless, interpretation of these results should be carefully considered.
M Nissensohn; A Sánchez-Villegas; D Fuentes Lugo; P Henríquez Sánchez; J Doreste Alonso; L Peña Quintana; C Ruano; N L Lowe; V Hall Moran; A L Skinner; M Warthon-Medina; L Serra-Majem
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-3
Journal Detail:
Title:  Critical reviews in food science and nutrition     Volume:  -     ISSN:  1549-7852     ISO Abbreviation:  Crit Rev Food Sci Nutr     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-3     Completed Date:  -     Revised Date:  2014-11-5    
Medline Journal Info:
Nlm Unique ID:  8914818     Medline TA:  Crit Rev Food Sci Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
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