Document Detail

Effect of zinc administration on pancreatic regeneration after 80% pancreatectomy.
MedLine Citation:
PMID:  9057188     Owner:  NLM     Status:  MEDLINE    
We studied the effect of oral zinc administration on functional and morphological regeneration of the remnant pancreas after 80% pancreatectomy in dogs. After 80% pancreatectomy, both endo- and exocrine function (assessed by the sum of plasma immunoreactive insulin on the intravenous glucose tolerance test and amylase output on the cerulein-secretin test) markedly deteriorated, the pancreatic regeneration rate (change in weight of the remnant pancreas between the time of surgery and autopsy) was very poor, and the zinc concentration in pancreatic tissue decreased in dogs fed the standard diet. In dogs fed the high-zinc diet, pancreatic function and regeneration rate were significantly improved, and the zinc concentration in pancreatic tissue was maintained. Early cell proliferation (assessed by ornithine decarboxylase activity. DNA synthesis, and proliferating cell nuclear antigen labeling index in the remnant pancreas) after pancreatectomy was significantly enhanced in the high-zinc diet group compared to the standard diet group. Correlation analyses between parameters of early cell proliferation and zinc concentration in pancreatic tissue yielded significant positive correlations, and the zinc concentration in pancreatic tissue was significantly correlated with both endo- and exocrine function and the pancreatic regeneration rate. These results suggest that a high-zinc diet after major pancreatectomy is effective in maintaining the zinc concentration in pancreatic tissue, which not only enhance early cell proliferation in the remnant pancreas but improves pancreatic endo- and exocrine function in the late period, promoting pancreatic regeneration.
K Kato; S Isaji; Y Kawarada; H Hibasami; K Nakashima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  14     ISSN:  0885-3177     ISO Abbreviation:  Pancreas     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-19     Completed Date:  1997-06-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  158-65     Citation Subset:  IM    
First Department of Surgery, Mie University School of Medicine, Japan.
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MeSH Terms
Blood Glucose / metabolism
Cell Division / drug effects
DNA / biosynthesis
Glucose Tolerance Test
Ornithine Decarboxylase / metabolism
Pancreas / cytology,  physiology*
Proliferating Cell Nuclear Antigen / analysis
Regeneration / drug effects*
Zinc / administration & dosage,  metabolism,  pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/Proliferating Cell Nuclear Antigen; 7440-66-6/Zinc; 9007-49-2/DNA; EC Decarboxylase

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