| Effect of zidovudine on blood composition of the pregnant and fetal baboon. | |
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MedLine Citation:
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PMID: 9166174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our purpose was to assess the effect of intravenous zidovudine on placental function and fetal well-being. STUDY DESIGN: Eighteen chronically instrumented third-trimester pregnant baboons and their fetuses were studied after 4- to 48-hour infusions of zidovudine to 14 mothers (0.8 to 2.0 mg/kg/hr) and 6 fetuses (0.2 to 0.22 mg/kg/hr of maternal weight). Fetal and maternal pH and blood gases, hematocrit, blood cell counts, clinical chemistries, electrolytes, and hormones were measured before and after the infusions. RESULTS: In both mother and fetus no significant differences were found between values in the control periods and those after infusions of zidovudine in any of the index values measured. CONCLUSION: Administration of zidovudine from 4 to 48 hours in the baboon was associated with no significant change in any biochemical index values in the mother or fetus. Thus comparable exposure of the human fetus to zidovudine during labor is not expected to affect these index values of placental function and fetal well-being. |
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Authors:
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S S Daniel; M Garland; R I Stark; M M Myers; P J Tropper |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 176 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-06-12 Completed Date: 1997-06-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1095-8 Citation Subset: AIM; IM; X |
Affiliation:
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Department of Anesthesiology, Columbia College of Physicians and Surgeons, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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drug effects Animals Corticotropin-Releasing Hormone / blood Female Fetal Blood / chemistry* Fetus / drug effects* Humans Hydrocortisone / blood Papio Placenta / drug effects, physiology Pregnancy Pregnancy, Animal / blood* Zidovudine / administration & dosage, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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AI32314/AI/NIAID NIH HHS; HD13063/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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30516-87-1/Zidovudine; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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