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Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse.
MedLine Citation:
PMID:  23035904     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective  To describe selected pharmacodynamic effects of detomidine and yohimbine when administered alone and in sequence. Study design  Randomized crossover design. Animals  Nine healthy adult horses aged 9 ± 4 years and weighing 561 ± 56 kg. Methods  Three dose regimens were employed in the current study. 1) 0.03 mg kg(-1) detomidine IV, 2) 0.2 mg kg(-1) yohimbine IV and 3) 0.03 mg kg(-1) detomidine IV followed 15 minutes later by 0.2 mg kg(-1) yohimbine IV. Each horse received all three treatments with a minimum of 1 week between treatments. Blood samples were obtained and plasma analyzed for detomidine and yohimbine concentrations by liquid chromatography-mass spectrometry. Behavioral effects, heart rate and rhythm, glucose, packed cell volume and plasma proteins were monitored. Results  Yohimbine rapidly reversed the sedative effects of detomidine in the horse. Additionally, yohimbine effectively returned heart rate and the percent of atrio-ventricular conduction disturbances to pre-detomidine values when administered 15 minutes post-detomidine administration. Plasma glucose was significantly increased following detomidine administration. The detomidine induced hyperglycemia was effectively reduced by yohimbine administration. Effects on packed cell volume and plasma proteins were variable. Conclusions and clinical relevance  Intravenous administration of yohimbine effectively reversed detomidine induced sedation, bradycardia, atrio-ventricular heart block and hyperglycemia.
Authors:
Heather K Dimaio Knych; Vanessa Covarrubias; Eugene P Steffey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  39     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  574-83     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Veterinary Anaesthesia and Analgesia. © 2012 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.
Affiliation:
K.L. Maddy Equine Analytical Chemistry Laboratory, School of Veterinary Medicine, University of California, Davis, CA, USA Department of Veterinary Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
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