| Effect of xylazine, detomidine, and a combination of xylazine and butorphanol on equine duodenal motility. | |
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MedLine Citation:
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PMID: 9582967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect on equine duodenal motility of some analgesic agents commonly used to treat colic. ANIMALS: 4 healthy adult healthy horses--2 mares and 2 geldings--which were carrying an indwelling gastric cannula made of silastic rubber. One horse also carried 2 long-term indwelling bipolar electrodes that had been sutured onto the duodenum and jejunum. PROCEDURE: To ensure an empty stomach, solid food was withheld from horses for around 20 hours prior to an experiment. Using videoendoscopic guidance, an 8-F catheter with 3 small, discrete pressure sensors was passed through the gastric cannula and directed into the proximal portion of the duodenum. Deflection of the recording pen, to which the catheter was attached, indicated a motile event in that section. Drugs (treatment) were given into the jugular vein in a randomized block design, 1 treatment/experiment, after a 1-hour baseline recording. Treatments were: 2 ml of 0.9% NaCl, xylazine (XYL, 0.5 mg/kg of body weight), detomidine (DET, 0.0125 mg/kg), or a xylazine/butorphanol combination (XYB, 0.5/0.05 mg/kg). Each horse received each treatment twice. All positive pressure peaks > 5 mm of Hg recorded from the most proximal sensor on the catheter were counted in 15-minute blocks. Each mean 15-minute posttreatment value was compared with the baseline value for that specific treatment. RESULTS: There was no significant difference between baseline values. All treatments significantly (P < 0.05) reduced frequency of pressure peaks below their respective pretreatment values, but to variable degrees and durations. Comparatively, XYL had the least effect, with mild, though significant, reduction for only the first 30 posttreatment minutes; DET and XYB caused a significant marked reduction for 1 hour after treatment. CONCLUSIONS: The profound suppressive effect of a routine dose of detomidine or xylazine/butorphanol combination on equine duodenal motility must be considered when using these agents for management of colic, especially when encouragement of intestinal motility is desirable. |
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Authors:
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A M Merritt; J A Burrow; C S Hartless |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of veterinary research Volume: 59 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-06-26 Completed Date: 1998-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 619-23 Citation Subset: IM |
Affiliation:
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Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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pharmacology* Animals Butorphanol / pharmacology* Drug Combinations Duodenum / physiology* Female Gastrointestinal Motility / drug effects* Horses / physiology* Imidazoles / pharmacology* Male Pressure Xylazine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Drug Combinations; 0/Imidazoles; 42408-82-2/Butorphanol; 7361-61-7/Xylazine; 76631-46-4/detomidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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