Document Detail

Effect of withdrawal of folic acid supplementation in maintenance hemodialysis patients.
MedLine Citation:
PMID:  8222379     Owner:  NLM     Status:  MEDLINE    
The requirement of patients on maintenance hemodialysis for dietary supplements of folic acid is controversial. High levels of folate carry the risk of toxicity as well as being unnecessary. We followed a group of 41 patients, not receiving erythropoietin, for 16 months after the cessation of folate supplementation (5 mg/day). Diet supplied 60-80 g protein and 120-260 micrograms folic acid/day. Red cell folate levels decreased linearly from a mean of 1931 +/- 888 micrograms/l (+/- SD) to 676 +/- 294 micrograms/l after 6 months before levelling off at 455 +/- 222 micrograms/l after 9 months. Mean values were unchanged 7 months later (491 +/- 319 micrograms/l). No patient developed folate deficiency. Hemoglobin values at 6, 9 and 16 months were slightly higher than the baseline value of 8.3 +/- 1.8 g/dl (p < 0.05). Mean corpuscular volumes were generally within normal limits, and vitamin B12 status was satisfactory. We conclude that folic acid supplements are unnecessary in adequately nourished hemodialysis patients who are not receiving erythropoietin.
J Westhuyzen; K Matherson; R Tracey; S J Fleming
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  40     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-21     Completed Date:  1993-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  96-9     Citation Subset:  IM    
Conjoint Renal Laboratory, Royal Brisbane Hospital, Australia.
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MeSH Terms
Anemia / etiology,  prevention & control
Folic Acid*
Hemoglobins / analysis
Middle Aged
Renal Dialysis* / adverse effects
Reg. No./Substance:
0/Hemoglobins; 11096-26-7/Erythropoietin; 59-30-3/Folic Acid
Comment In:
Clin Nephrol. 1994 Aug;42(2):136-7   [PMID:  7955576 ]

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