Document Detail


Effect of whole cottonseed on serum constituents, fragility of erythrocyte cells, and reproduction of growing Holstein heifers.
MedLine Citation:
PMID:  8961108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 431-d experiment was conducted to determine the effects of whole cottonseed containing gossypol (7400 mg/kg) on growth and development from weaning until pregnancy in Holstein heifers. Treatment diets (n = 5) contained 0, 15, or 30% whole cottonseed. The basal diet included alfalfa hay, corn grain, soybean meal, molasses, and dicalcium phosphate. Gossypol content of the treatment diets was 0, 1300, and 2000 mg/kg, and gossypol content in feces was 0, 290, and 1170 mg/kg, respectively, for treatments containing 0, 15, and 30% whole cottonseed. Estimated ingestion of gossypol (accumulated) was 0, 8, and 12 g/kg of BW, respectively, for treatments containing 0, 15, and 30% whole cottonseed during the 431-d experiment. Erythrocyte fragility was similar among treatment groups on d -3; on d 228, erythrocyte fragility was similar for heifers fed treatments containing 0 and 15% whole cottonseed, but was lower than that for heifers fed the 30% whole cottonseed diet. However, on d 430, fragility of erythrocytes increased linearly as the percentage of whole cottonseed increased. Clinical profiles of serum suggest possible impairment of liver and kidney function on d 144 and 430. Age and BW at onset of puberty and pregnancy rates were similar among treatments. One heifer fed the 30% whole cottonseed died on d 396, possibly from gossypol toxicosis. Long-term dietary supplementation at 15 to 30% whole cottonseed for long periods should be examined further for gossypol content and toxicity response of heifers and for effects on growth and development.
Authors:
J Colin-Negrete; H E Kiesling; T T Ross; J F Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dairy science     Volume:  79     ISSN:  0022-0302     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-06     Completed Date:  1997-03-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2016-23     Citation Subset:  IM    
Affiliation:
Department of Animal and Range Sciences, New Mexico State University, Las Cruces 88003, USA.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed* / analysis
Animals
Bilirubin / blood
Blood Glucose / metabolism
Blood Proteins / metabolism
Blood Urea Nitrogen
Cattle / physiology*
Cholesterol / blood
Cottonseed Oil*
Electrolytes / blood
Female
Gossypol / analysis
Lactation / physiology
Osmotic Fragility*
Pregnancy
Reproduction*
Tissue Distribution
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Blood Proteins; 0/Cottonseed Oil; 0/Electrolytes; 0/Triglycerides; 303-45-7/Gossypol; 57-88-5/Cholesterol; 635-65-4/Bilirubin

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