| Effect of whole-body irradiation on transcription in the rat thymus. | |
| | |
MedLine Citation:
|
PMID: 1079799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Studies were carried out to elucidate the mechanism underlying the impairment in RNA synthesis in the rat thymus after whole-body exposure to X-rays (1000 rad). The ability of thymus nuclei to catalyse RNA polymerization in vitro was adversely affected in irradiated rats. Further experiments showed that whole-body irradiation caused a considerable decrease in both the activity of RNA polymerase and the template efficiency of chromatin but not in that of DNA isolated from chromatin. These radiation-induced changes in transcription seem to arise partly from the direct effect of radiation on the thymus itself and partly from the abscopal mechanism(s). |
| | |
Authors:
|
M S Patil; D S Pradhan; A Sreenivasan |
Related Documents
:
|
990319 - Purification and characterization of human endonucleases specific for damaged dna. anal... 21380739 - Dna adducts and strand breaks in workers exposed to vapours and aerosols of bitumen: as... 3902079 - Thymine lesions produced by ionizing radiation in double-stranded dna. 5305089 - Ultraviolet inactivation and photoproducts of transforming dna irradiated at low temper... 17704329 - The early and initiation processes of radiation-induced bystander effects involved in t... 3186689 - Photochemical crosslinking of bacteriophage t4 single-stranded dna-binding protein (gp3... 9220389 - Detection of enteroviral rna and specific dna of herpesviruses by multiplex genome ampl... 4562749 - A transcribing activity induced by satellite phage p4. 21047779 - Phosphatidylinositol 3-kinase (pi3k) signaling via glycogen synthase kinase-3 (gsk-3) r... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of radiation biology and related studies in physics, chemistry, and medicine Volume: 27 ISSN: 0020-7616 ISO Abbreviation: Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. Publication Date: 1975 Apr |
Date Detail:
|
Created Date: 1975-10-03 Completed Date: 1975-10-03 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0374725 Medline TA: Int J Radiat Biol Relat Stud Phys Chem Med Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 363-70 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carbon Radioisotopes Chromatin / radiation effects DNA / radiation effects DNA-Directed RNA Polymerases / metabolism Male Phosphorus Radioisotopes RNA / biosynthesis Radiation Genetics* Rats Thymus Gland / enzymology, metabolism, radiation effects* Transcription, Genetic / radiation effects* X-Rays |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Radioisotopes; 0/Chromatin; 0/Phosphorus Radioisotopes; 63231-63-0/RNA; 9007-49-2/DNA; EC 2.7.7.6/DNA-Directed RNA Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prophage inductive efficiency of alkylating agents and radiations.
Next Document: Chain reactions and radiosensitization: model enzyme studies.