Document Detail


Effect of whole-body irradiation on transcription in the rat thymus.
MedLine Citation:
PMID:  1079799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were carried out to elucidate the mechanism underlying the impairment in RNA synthesis in the rat thymus after whole-body exposure to X-rays (1000 rad). The ability of thymus nuclei to catalyse RNA polymerization in vitro was adversely affected in irradiated rats. Further experiments showed that whole-body irradiation caused a considerable decrease in both the activity of RNA polymerase and the template efficiency of chromatin but not in that of DNA isolated from chromatin. These radiation-induced changes in transcription seem to arise partly from the direct effect of radiation on the thymus itself and partly from the abscopal mechanism(s).
Authors:
M S Patil; D S Pradhan; A Sreenivasan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation biology and related studies in physics, chemistry, and medicine     Volume:  27     ISSN:  0020-7616     ISO Abbreviation:  Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-10-03     Completed Date:  1975-10-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374725     Medline TA:  Int J Radiat Biol Relat Stud Phys Chem Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  363-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Radioisotopes
Chromatin / radiation effects
DNA / radiation effects
DNA-Directed RNA Polymerases / metabolism
Male
Phosphorus Radioisotopes
RNA / biosynthesis
Radiation Genetics*
Rats
Thymus Gland / enzymology,  metabolism,  radiation effects*
Transcription, Genetic / radiation effects*
X-Rays
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Chromatin; 0/Phosphorus Radioisotopes; 63231-63-0/RNA; 9007-49-2/DNA; EC 2.7.7.6/DNA-Directed RNA Polymerases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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