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Effect of weight loss and regain on adipose tissue distribution, composition of lean mass and resting energy expenditure in young overweight and obese adults.
MedLine Citation:
PMID:  23381557     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:Although weight cycling is frequent in obese patients, the adverse consequences on body composition and an increased propensity to weight gain remain controversial.Objective:We investigated the effect of intentional weight loss and spontaneous regain on fat distribution, the composition of lean mass and resting energy expenditure (REE).Design:Weight regainers (30% of loss, n=27) and weight-stable subjects (within <±20% of weight change, n=20) were selected from 103 overweight and obese subjects (body mass index 28-43 kg m(-2), 24-45 years) who passed a 13-week low-calorie diet intervention. REE and body composition (by densitometry and whole-body magnetic resonance imaging) were examined at baseline, after weight loss and at 6 months of follow-up.Results:Mean weight loss was -12.3±3.3 kg in weight-stable subjects and -9.0±4.3 kg in weight regainers (P<0.01). Weight regain was incomplete, accounting for 83 and 42% of weight loss in women and men. Regain in total fat and different adipose tissue depots was in proportion to weight regain except for a higher regain in adipose tissue of the extremities in women and a lower regain in extremity and visceral adipose tissue in men. In both genders, regain in skeletal muscle of the trunk lagged behind skeletal muscle regain at the extremities. In contrast to weight-stable subjects, weight regainers showed a reduced REE adjusted for changes in organ and tissue masses after weight loss (P<0.001).Conclusion:Weight regain did not adversely affect body fat distribution. Weight loss-associated adaptations in REE may impair weight loss and contribute to weight regain.International Journal of Obesity advance online publication, 5 February 2013; doi:10.1038/ijo.2013.1.
Authors:
A Bosy-Westphal; B Schautz; M Lagerpusch; M Pourhassan; W Braun; K Goele; M Heller; C-C Glüer; M J Müller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-05
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  -     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Human Nutrition and Food Science, Christian-Albrechts University, Kiel, Germany.
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