| Effect of water soluble polymer, polyethyleneglycol, and glass-forming compounds on cell fusion. | |
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MedLine Citation:
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PMID: 6985109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell fusion of Molt T-cells was investigated in the presence of water soluble polymer, polyethyleneglycol (PEG) and glass-forming monomers. In cell fusion with PEG only, inactivation of the cell occurred within 2 min. However, in the presence of PEG and water soluble polymer, most of the fused and unfused cells lived even after fusion times of more than 10 min. It was observed that water soluble polymer prevented the inactivation of cells during fusion as a protectant. As the result, ratio of fused cells increased in the presence of water soluble polymers. Some glass-forming monomers used as new fusogens such as M-23G (n = 23) and M-50G (n = 50) monomers having long oxyethylene chains in the methoxypolyethyleneglycol methacrylate, CH3O-(-CH2CH2-O)n-CO-C(CH3) = CH2 as well as PEG #2000 indicated large promoting and protecting effects on cell fusion. |
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Authors:
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F Yoshii; I Kaetsu |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Zeitschrift für Naturforschung. Section C: Biosciences Volume: 37 ISSN: 0341-0382 ISO Abbreviation: Z. Naturforsch., C, Biosci. Publication Date: 1982 Nov-Dec |
Date Detail:
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Created Date: 1983-07-29 Completed Date: 1983-07-29 Revised Date: 2009-06-08 |
Medline Journal Info:
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Nlm Unique ID: 7801143 Medline TA: Z Naturforsch C Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1234-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Fusion
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drug effects* Cell Line Humans Leukemia, Lymphoid Polyethylene Glycols / pharmacology* Polymers / pharmacology* Povidone / pharmacology Structure-Activity Relationship T-Lymphocytes / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Polyethylene Glycols; 0/Polymers; 9003-39-8/Povidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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