Document Detail

Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs.
MedLine Citation:
PMID:  18607964     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The results of this study indicate that coenzyme Q10 reduces cochlear oxidative stress induced by acoustic overstimulation. OBJECTIVE: We investigated the effects of coenzyme Q10 on noise-induced hearing loss in guinea pigs. MATERIALS AND METHODS: Animals received water-soluble coenzyme Q10 intraperitoneally 2 h before noise exposure. Seven days after noise exposure (130 dB sound pressure level for 3 h), the auditory brainstem response (ABR) threshold shift and cochlear hair cell damage were assessed. RESULTS: We observed that the ABR threshold shift was significantly less in the coenzyme Q10 group than in the vehicle control group. In addition, the percentage of missing outer hair cells was lower in the coenzyme Q10 group than in the control group. Moreover, 2 days after administration of coenzyme Q10, increased antioxidative activity in the cochlea, as measured by analysis of hydroxy radical scavenging activity by electron spin resonance was observed.
Yoshinobu Hirose; Kazuma Sugahara; Takefumi Mikuriya; Makoto Hashimoto; Hiroaki Shimogori; Hiroshi Yamashita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  128     ISSN:  1651-2251     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1071-6     Citation Subset:  IM    
Department of Otolaryngology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
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MeSH Terms
Aldehydes / metabolism
Antioxidants / pharmacology*
Auditory Threshold
Electron Spin Resonance Spectroscopy
Evoked Potentials, Auditory, Brain Stem
Free Radical Scavengers / pharmacology
Guinea Pigs
Hair Cells, Auditory, Outer / cytology
Hearing Loss, Noise-Induced / prevention & control*
Hydroxyl Radical / metabolism
Ubiquinone / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Aldehydes; 0/Antioxidants; 0/Free Radical Scavengers; 1339-63-5/Ubiquinone; 29343-52-0/4-hydroxy-2-nonenal; 303-98-0/coenzyme Q10; 3352-57-6/Hydroxyl Radical

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