Document Detail


Effect of the water extracts of propolis on stimulation and inhibition of different cells.
MedLine Citation:
PMID:  19003017     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The water extracts of propolis (WEP) could inhibit growth of different cell lines namely McCoy, HeLa, SP2/0, HEp-2, and BHK21 and stimulate growth of normal cell named human lymphocyte, rat kidney, rat liver, and rat spleen. In these experiments 1 and 2 mg of WEP were added to 1 ml RPMI media with 5% FCS. Cell counts and cell viability of propolis-treated and propolis-free cells were assessed by Trypan blue dye exclusion test and MTT assay. The results showed that in case of McCoy, HeLa, SP20, HEp-2, and BHK21 cell lines, the water extracts of propolis could inhibit cell growth as well as reduction on size of the cells. In contrast the same amount of WEP could stimulate growth of normal cells up to 60% with the same concentration used for cell lines. Thus our study indicates that although WEP consists only of the soluble part of propolis, it enables to inhibit different cell lines and increase growth of normal cells. This indicates also that WEP contains the specific compounds with bioactivity against cell lines. Although propolis contain different number of compounds it is clear that WEP has enough biological compounds useful for the treatment of some diseases, medical and related applications.
Authors:
Mohsen Fathi Najafi; Fatemeh Vahedy; Mohammad Seyyedin; Hamid Reza Jomehzadeh; Kazem Bozary
Related Documents :
3257717 - Potentiation by a biscoclaurine alkaloid, cepharanthine, of the toxicity of conjugates ...
4288837 - Programming of poliovirus inhibition of deoxyribonucleic acid synthesis in hela cells.
2285237 - Modulation of cytotoxic effect of anticancer drugs by dipyridamole in hela cells in vitro.
4796877 - Effect of metabolic inhibitors on nuclear pore formation during the hela s3 cell cycle.
3200447 - Quantitative immunoassay of recombinant murine neuroleukin.
6822777 - Preparation and steroidogenic properties of purified zona fasciculata and zona reticula...
Publication Detail:
Type:  Journal Article     Date:  2007-04-11
Journal Detail:
Title:  Cytotechnology     Volume:  54     ISSN:  0920-9069     ISO Abbreviation:  Cytotechnology     Publication Date:  2007 May 
Date Detail:
Created Date:  2008-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807027     Medline TA:  Cytotechnology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  -    
Affiliation:
Department of Veterinary Research and Biotechnology, Razi Vaccine and Serum Research Institute, Ahmadabad Ave, Mashhad, Iran, najafi99@yahoo.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Using cell size kinetics to determine optimal harvest time for Spodoptera frugiperda and Trichoplusi...
Next Document:  Developement of serum-free media in CHO-DG44 cells using a central composite statistical design.