Document Detail


Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects.
MedLine Citation:
PMID:  16822278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To assess the effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem.
METHODS: In a randomized cross-over study with two phases, 10 healthy subjects ingested 10 mg of zolpidem with or without oral voriconazole pretreatment. The concentrations of zolpidem were measured in plasma up to 24 h and pharmacodynamic variables were monitored for 12 h.
RESULTS: Voriconazole increased the peak plasma concentration of zolpidem by 1.23-fold [P < 0.05; 90% confidence interval (CI) 1.05, 1.45] and the area under the plasma zolpidem concentration-time curve by 1.48-fold (P < 0.001; 90% CI 1.29, 1.74). The time to peak plasma zolpidem concentration was unchanged by voriconazole but the half-life was prolonged from 3.2 to 4.1 h (P < 0.01; 95% CI on the difference 0.27, 1.45). The pharmacodynamics of zolpidem were unaffected by voriconazole.
CONCLUSION: Voriconazole caused a moderate increase in exposure to zolpidem in healthy young subjects but no clear pharmacodynamic changes were observed between the groups.
Authors:
Teijo I Saari; Kari Laine; Kari Leino; Mika Valtonen; Pertti J Neuvonen; Klaus T Olkkola
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-07-06
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  63     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-18     Completed Date:  2007-06-07     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  116-20     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology and Intensive Care and the Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland. teijo.saari@tyks.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Antifungal Agents / pharmacology*
Cross-Over Studies
Drug Interactions
Humans
Hypnotics and Sedatives / pharmacokinetics*
Male
Pyridines / pharmacokinetics*
Pyrimidines / pharmacology*
Triazoles / pharmacology*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Hypnotics and Sedatives; 0/Pyridines; 0/Pyrimidines; 0/Triazoles; 0/voriconazole; 7K383OQI23/zolpidem
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