Document Detail

Effect of voluntary exercise and food restriction in response to lipopolysaccharide in hamsters.
MedLine Citation:
PMID:  7759414     Owner:  NLM     Status:  MEDLINE    
We tested the hypothesis that voluntary running and moderate food restriction alter the acute phase response (APR), one index of nonspecific immune function. Hamsters were kept sedentary or permitted to run and were fed ad libitum or had food restricted for 20 days and were then injected intraperitoneally with saline or lipopolysaccharide (LPS). Fever and circulating interleukin-6, serum amyloid A (SAA), serum iron, and cortisol were measured by biotelemetry, B-9 cell growth assay, indirect enzyme-linked immunosorbent assay, colorimetric analysis, and radioimmunoassay, respectively. The febrile temperature; hypoferremia; and elevation of circulating interleukin-6, SAA, and cortisol after LPS injection were not altered by exercise. Because baseline temperatures were elevated in the exercised hamsters, the change in temperature in response to LPS was less than it was in the sedentary hamsters. Food restriction significantly decreased SAA and elevated cortisol after LPS injection and depressed the absolute temperature to which the core temperature rose in response to LPS in one trial but not in another. Because food restriction depressed baseline temperatures, it also affected the change in temperature after LPS injection. The hypoferremic response to LPS was inhibited in hamsters that were both food restricted and permitted to run. We conclude that exercise does not enhance the APR to a low dose of LPS, whereas food restriction and the combination of exercise and food restriction depress some portions of the APR in hamsters.
C A Conn; W E Kozak; P C Tooten; E Gruys; K T Borer; M J Kluger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  78     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-29     Completed Date:  1995-06-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  466-77     Citation Subset:  IM    
Institute for Basic and Applied Medical Research, Lovelace Institutes, Albuquerque, New Mexico 87108, USA.
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MeSH Terms
Acute-Phase Reaction
Amyloid / blood
Body Temperature / drug effects,  physiology
Eating / physiology*
Hydrocortisone / blood
Interleukin-6 / metabolism
Iron / blood
Lipopolysaccharides / pharmacology*
Motor Activity / drug effects,  physiology
Physical Exertion / physiology*
Stress, Physiological / physiopathology
Grant Support
Reg. No./Substance:
0/Amyloid; 0/Interleukin-6; 0/Lipopolysaccharides; 50-23-7/Hydrocortisone; 7439-89-6/Iron

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