Document Detail

Effect of voluntary exercise on 3'-methyl-4-dimethylaminoazobenzene-induced hepatomas in male Jc1:Wistar rats.
MedLine Citation:
PMID:  8105485     Owner:  NLM     Status:  MEDLINE    
The effect of voluntary exercise on 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB)-induced hepatomas was investigated in male Jc1:Wistar rats. Beginning at 10 weeks of age, animals were divided into two groups (sedentary and exercise) and housed in individual cages. Food intake and wheel exercise were automatically controlled in the cages of the exercise group. Body weights were monitored throughout the study. Food availability was controlled in order to equate length and weight gain. From 27 weeks to termination of the study at 62 weeks, all animals were administered 3'-Me-DAB in the diet at a dose level of 0.0177 g/day/kg body wt. All animals were sacrificed at 62 weeks of age. The incidence of hepatomas was significantly lower in the exercise group as compared with the sedentary group (0% and 65%, respectively). Liver weight was significantly greater in the exercise group compared with sedentary animals without hepatomas. The weight of epididymal fat pads was significantly lower in the exercise group. Serum alkaline phosphate was significantly higher in the exercise group as compared with the sedentary group. Serum gamma-glutamyl-transpeptidase levels were higher in the sedentary group than in the exercise group. In addition, gamma-glutamyl-transpeptidase levels were significantly higher in sedentary animals with hepatomas than in sedentary animals without hepatomas. These results demonstrate that voluntary exercise decreases 3'-Me-DAB-induced hepatomas and that this decrease is associated with an increase in serum alkaline phosphatase and a decrease in serum gamma-glutamyl-transpeptidase levels.
T Ikuyama; T Watanabe; Y Minegishi; H Osanai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  204     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-11-17     Completed Date:  1993-11-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Physical Fitness Research Institute, Meiji Life Foundation and Welfare, Tokyo, Japan.
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MeSH Terms
Alkaline Phosphatase / blood
Liver / enzymology
Liver Neoplasms, Experimental / chemically induced*,  enzymology
Methyldimethylaminoazobenzene / toxicity*
Physical Exertion*
Rats, Wistar
gamma-Glutamyltransferase / metabolism
Reg. No./Substance:
55-80-1/Methyldimethylaminoazobenzene; EC; EC Phosphatase

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