Document Detail

Effect of volume recruitment on response to surfactant treatment in rabbits with lung injury.
MedLine Citation:
PMID:  9310005     Owner:  NLM     Status:  MEDLINE    
We determined if surfactant treatment effect can be enhanced by mechanical volume recruitment during surfactant administration by measuring functional residual capacity, tidal volume, the alveolar portion of tidal volume, dynamic compliance of the respiratory system, a/A ratio, and PaCO2 by measuring before and after surfactant administration to rabbits with lung injury induced by airway lavage. There was improvement in all lung function indices when surfactant was given with volume recruitment, but when surfactant was given without volume recruitment, the only index to show significant improvement was a/A ratio of oxygenation. These results support the hypothesis that mechanical recruitment of terminal airspaces from a previously unventilated compartment will enhance the effectiveness of surfactant replacement by facilitating the distribution of instilled surfactant to this compartment.
M Krause; T Olsson; A B Law; R A Parker; D P Lindstrom; H W Sundell; R B Cotton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  156     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-28     Completed Date:  1997-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  862-6     Citation Subset:  AIM; IM    
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
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MeSH Terms
Combined Modality Therapy
Disease Models, Animal
Drug Evaluation, Preclinical
Functional Residual Capacity / drug effects
Infant, Newborn
Lung Compliance / drug effects
Pulmonary Gas Exchange / drug effects
Pulmonary Surfactants / therapeutic use*
Respiration, Artificial / methods*
Respiratory Distress Syndrome, Newborn / therapy*
Tidal Volume / drug effects
Grant Support
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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