| Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice | |
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MedLine Citation:
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PMID: 19459309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the effect of the volatile oil from nutmeg on liver microsomal cytochrome P450 in mice. METHOD: Mice were administered the volatile oil from nutmeg at 0.4, 0.8 and 1.2 mg x g(-1), respectively, twice a day for 10 days. And then, the contents of liver microsomal cytochrome P450 (CYP), cytochrome b5 (Cytb5), MDA and GST in serum were examined by UV chromatography method. RESULT: The contents of liver CYP, Cytb5 and GST in serum were increased significantly (P < 0.01) and the contents of MDA was reduced significantly (P < 0.01). CONCLUSION: The volatile oil from nutmeg showed induction effect on the hepatic microsomal CYP in mice. |
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Authors:
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Runying Zhao; Wei Wang; Lini Zhao; Zhao Li; Junping Wang |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Volume: 34 ISSN: 1001-5302 ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-05-22 Completed Date: 2009-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913656 Medline TA: Zhongguo Zhong Yao Za Zhi Country: China |
Other Details:
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Languages: chi Pagination: 447-9 Citation Subset: IM |
Affiliation:
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Dept of Pharmacology, Shenyang Medical College, Shenyang 110034, China. zhaorunying@sohu.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytochrome P-450 Enzyme System / metabolism* Cytochromes b5 / metabolism Drugs, Chinese Herbal / pharmacology Female Gene Expression Regulation, Enzymologic Male Mice Microsomes, Liver / drug effects*, enzymology Myristica fragrans / chemistry* Oils, Volatile / pharmacology* Plant Oils / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/Oils, Volatile; 0/Plant Oils; 9035-39-6/Cytochromes b5; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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