| Effect of volatile anesthetics on the hepatic UDP-glucuronic acid pathway in mice. | |
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MedLine Citation:
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PMID: 2167093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Large, rapid decreases in hepatic UDP-glucuronic acid concentrations occur in rats following exposure to myriad chemicals. In fact, 80% reductions in UDP-glucuronic acid occur within minutes after exposure to inhalation anesthetics. The present study was designed to determine whether this decrease in hepatic UDP-glucuronic acid may be due to (a) a decrease in the precursor UDP-glucose; (b) decreased activity of UDP-glucose dehydrogenase, which oxidizes UDP-glucose to UDP-glucuronic acid; (c) increased activity of UDP-glucuronosyltransferases; or (d) increased activity of nucleotide pryophosphatase, which degrades UDP-glucuronic acid to glucuronic acid-1-phosphate. Exposure to halothane, isoflurane and sevoflurane decreased UDP-glucuronic acid concentrations by 40-52% as compared to that in unanesthetized control mice. No sex-dependent or anesthetic-induced effects of UDP-glucose levels and the activities of UDP-glucose dehydrogenase and UDP-glucuronosyltransferase were observed. Nucleotide pyrophosphatase activity was increased by 47-65% in female mice after inhalation of halothane, isoflurane and sevoflurane. The apparent Vmax for hydrolysis of 4-nitrophenol thymidine 5'-monophosphate ester by nucleotide pyrophosphatase was increased by 56-80% in female mice, whereas the apparent Km was unchanged. These alterations in nucleotide pyrophosphate kinetics may be responsible, in part, for the marked decrease of hepatic UDP-glucuronic acid concentrations by the volatile anesthetics. |
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Authors:
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J B Watkins; D R Engles; L V Beck |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical pharmacology Volume: 40 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-09-18 Completed Date: 1990-09-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 731-5 Citation Subset: IM |
Affiliation:
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Pharmacology Section, Indiana University School of Medicine, Bloomington 47405. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics
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pharmacology* Animals Ethers / pharmacology Female Halothane / pharmacology Isoflurane / pharmacology Liver / drug effects, metabolism* Male Methyl Ethers* Mice Pyrophosphatases / analysis Sex Factors Urethane / pharmacology Uridine Diphosphate Glucuronic Acid / analysis, metabolism* Uridine Diphosphate Sugars / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Ethers; 0/Methyl Ethers; 0/Uridine Diphosphate Sugars; 151-67-7/Halothane; 2616-64-0/Uridine Diphosphate Glucuronic Acid; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 51-79-6/Urethane; EC 3.6.1.-/Pyrophosphatases; EC 3.6.1.9/nucleotide pyrophosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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