| Effect of vitamins C and E on toxicity and mutagenicity of hexavalent chromium in rat and guinea pig. | |
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MedLine Citation:
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PMID: 1986283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of simultaneous pretreatment with vitamins C and E on the toxicity and mutagenicity of K2Cr2O7 in rats and guinea pigs was evaluated. Dietary pretreatment of Cr(VI)-intoxicated rats with ascorbic acid or alpha-tocopherol normalized vitamin C levels in lungs but not in kidneys. The synergistic preventive effect of both vitamins was confirmed in the production of lipoperoxides in Cr(VI)-intoxicated rats. Simultaneous administration of vitamins C and E in guinea pigs prevented the decrease of vitamin C levels provoked by the oxidative effects of Cr(VI). The results of the micronucleus test in bone marrow showed that it was vitamin C that caused the antimutagenic effect against bichromate, in both rats and guinea pigs. The effect of vitamin E was demonstrated only in an increase of the ratio of NCE to PCE, i.e., in a decrease of the cytotoxic but not the mutagenic effects of hexavalent chromium. |
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Authors:
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D Chorvatovicová; E Ginter; A Kosinová; Z Zloch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mutation research Volume: 262 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-02-12 Completed Date: 1991-02-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 41-6 Citation Subset: IM |
Affiliation:
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Institute of Experimental Biology and Ecology, Slovak Academy of Sciences, Bratislava, Czechoslovakia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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metabolism Animals Ascorbic Acid / pharmacology* Drug Synergism Guinea Pigs Kidney / metabolism Liver / metabolism Lung / metabolism Male Mutation / drug effects* Potassium Dichromate / toxicity* Rats Rats, Inbred Strains Testis / metabolism Vitamin E / pharmacology* |
| Chemical | |
Reg. No./Substance:
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1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 7778-50-9/Potassium Dichromate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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