Document Detail

Effect of vitamin A on diarrhoeal and respiratory complications of measles.
MedLine Citation:
PMID:  8116059     Owner:  NLM     Status:  MEDLINE    
A randomized placebo-controlled trial of high dose vitamin A in acute measles was performed in Nairobi, Kenya to determine if it reduced the incidence or severity of diarrhoeal and respiratory complications. On enrollment laryngotracheobronchitis (LTB) pneumonia, diarrhoea and otitis media were each found in 45-80% of children in the treatment and placebo groups. While 4 of 119 cases of LTB in the placebo group progressed to grade III (loud stridor, markedly diminished air entry, chest indrawing, cyanosis), none of 116 in the vitamin A group did. Episodes of diarrhoea, but not pneumonia, resolved faster and were less severe in the vitamin A group. There were no differences in the incidences of pneumonia, LTB or diarrhoea during hospitalization, but children treated with vitamin A had a lower rate of developing otitis media. The overall case fatality rate was 2.7% and did not differ by group. These findings, along with those from three other trials in Africa, suggest that high dose vitamin A reduces the severity of complications during measles.
F O Ogaro; V A Orinda; F E Onyango; R E Black
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tropical and geographical medicine     Volume:  45     ISSN:  0041-3232     ISO Abbreviation:  Trop Geogr Med     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-28     Completed Date:  1994-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376231     Medline TA:  Trop Geogr Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  IM    
Department of Paediatrics, University of Nairobi, Kenya.
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MeSH Terms
Acute Disease
Bronchitis / etiology,  prevention & control*
Child, Preschool
Diarrhea / etiology,  prevention & control*
Measles / complications*
Pneumonia / etiology,  prevention & control*
Vitamin A / administration & dosage*
Reg. No./Substance:
11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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