Document Detail

Effect of vitamin A deficiency on retinol and retinyl esters contents in rat brain.
MedLine Citation:
PMID:  19817120     Owner:  NLM     Status:  MEDLINE    
In the present study, the pattern of vitamin A (retinol and retinyl esters) contents in discrete brain areas was investigated in Wistar rats (both sexes of 10-12 weeks old) fed on vitamin A deficient diet. The animals were placed on standard laboratory diet for the control animals and a vitamin A deficient diet for the experimental animals for 20 weeks. At the end of this period, brain retinol and retinyl esters contents from control and vitamin A deficient diet animals were measured by HPLC. Retinol was the predominant form of retinoids in male rat brains (77 to 92% of total retinol) and retinyl esters were the predominant form in female brain rats (4 to 44% of total retinol). The abundant ester in both sexes was the retinyl linoleate. Olfactory bulb and the midbrain contained the highest quantities of retinol and retinyl esters in both sexes. On the other hand, the vitamin A deficient diet significantly decreased the retinoid contents in male brain, in olfactory bulb (-30.7%), hindbrain (-46.2%) and increased it in forebrain (84.3%) and midbrain (2.2%). Total retinol was decreased in olfactory bulb (-38.7%), forebrain (-44.5%) and midbrain (-30.7%) and increased in hindbrain (23.4%) of vitamin A deficient female rats. In conclusion, retinol and retinyl esters were the brain compounds heterogeneously distributed throughout the brain areas in both the sexes and were significantly affected by vitamin A deficiency status as well.
Asma Arfaoui; Issad Nasri; Samira Boulbaroud; Ali Ouichou; Abdelhalim Mesfioui
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  12     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-10-12     Completed Date:  2009-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  939-48     Citation Subset:  IM    
Unit of Nervous and Endocrine Physiology, Laboratory of Genetics and Neuroendocrine Physiology, Department of Biology, Faculty of Science-Kenitra, Ibn Tofail University, PB 133, 14000 Kenitra, Morocco.
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MeSH Terms
Brain / anatomy & histology,  metabolism
Brain Chemistry*
Esters / analysis*
Rats, Wistar
Vitamin A / analogs & derivatives,  analysis*
Vitamin A Deficiency / metabolism*
Reg. No./Substance:
0/Esters; 11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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